...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model
【24h】

Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model

机译：普伐他汀诱导小鼠模型中的胎盘生长因子（PGF）并改善先兆子痫

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Preeclampsia is a relatively common pregnancy-related disorder. Both maternal and fetal lives will be endangered if it proceeds unabated. Recently, the placenta-derived anti-angiogenic factors, such as soluble fms-like tyrosine kinase-1 (sFLT1) and soluble endoglin (sENG), have attracted attention in the progression of preeclampsia. Here, we established a unique experimental model to test the role of sFLT1 in preeclampsia using a lentiviral vector-mediated placenta-specific expression system. The model mice showed hypertension and proteinuria during pregnancy, and the symptoms regressed after parturition. Intrauterine growth restriction was also observed. We fuerther showed that pravastatin induced the VEGF-like angiogenic factor placental growth factor (PGF) and ameliorated the symptoms. We conclude that our experimental preeclamptic murine model phenocopies the human case, and the model identifies low-dose statins and PGF as candidates for preeclampsia treatment.
机译：子痫前期是相对常见的妊娠相关疾病。如果继续进行下去，孕产妇和胎儿的生命都将受到威胁。最近，胎盘来源的抗血管生成因子，例如可溶性fms样酪氨酸激酶1（sFLT1）和可溶性内皮糖蛋白（sENG），在先兆子痫的发展中引起了人们的关注。在这里，我们建立了一个独特的实验模型，使用慢病毒载体介导的胎盘特异性表达系统来测试sFLT1在先兆子痫中的作用。模型小鼠在怀孕期间显示出高血压和蛋白尿，并且在分娩后症状逐渐恶化。还观察到宫内生长受限。我们进一步证明普伐他汀可诱导VEGF样血管生成因子胎盘生长因子（PGF）并改善症状。我们得出的结论是，我们的实验性先兆子痫小鼠模型在表型上复制了人类病例，并且该模型将低剂量他汀类药物和PGF确定为先兆子痫治疗的候选药物。

著录项

  • 来源
  • 作者

    Keiichi Kumasawa; Masahito Ikawa; Hiroyasu Kidoya; Hidetoshi Hasuwa; Tomoko Saito-Fujita; Yuka Morioka; Nobuyuki Takakura; Tadashi Kimura; Masaru Okabe;

  • 作者单位

    Departments of Experimental Genome Research, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan Departments of Department of Obstetrics and Gynecology, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan;

    Departments of Experimental Genome Research, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan;

    Departments of Signal Transduction, Research Institute for Microbial Diseases, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan;

    Departments of Experimental Genome Research, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan;

    Departments of Experimental Genome Research, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba 263-8555, Japan;

    Departments of Experimental Genome Research, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan Institute for Genetic Medicine, Hokkaido University. Sapporo 060-0815, Japan;

    Departments of Signal Transduction, Research Institute for Microbial Diseases, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan;

    Departments of Department of Obstetrics and Gynecology, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan;

    Departments of Experimental Genome Research, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    3-hydroxy-3-methyl-glutaryl-CoA; hemorytic anemia, elevated liver enzymes, and low platelet count; trophoblast;

    机译：3-羟基-3-甲基戊二酰辅酶A;溶血性贫血;肝酶升高和血小板计数低;滋养细胞;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号