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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Correlated genotypes in friendship networks
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Correlated genotypes in friendship networks

机译：友谊网络中的相关基因型

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It is well known that humans tend to associate with other humans who have similar characteristics, but it is unclear whether this tendency has consequences for the distribution of genotypes in a population. Although geneticists have shown that populations tend to stratify genetically, this process results from geographic sorting or assortative mating, and it is unknown whether genotypes may be correlated as a consequence of nonreproductive associations or other processes. Here, we study six available genotypes from the National Longitudinal Study of Adolescent Health to test for genetic similarity between friends. Maps of the friendship networks show clustering of genotypes and, after we apply strict controls for population stratification, the results show that one genotype is positively correlated (homophily) and one genotype is negatively correlated (heterophily). A replication study in an independent sample from the Framingham Heart Study verifies that DRD2 exhibits significant homophily and that CYP2A6 exhibits significant heterophily. These unique results show that homophily and heterophily obtain on a genetic (indeed, an allelic) level, which has implications for the study of population genetics and social behavior. In particular, the results suggest that association tests should include friends' genes and that theories of evolution should take into account the fact that humans might, in some sense, be metagenomic with respect to the humans around them.
机译：众所周知，人类倾向于与具有相似特征的其他人类交往，但是尚不清楚这种趋势是否会对人群中基因型的分布产生影响。尽管遗传学家已经表明种群倾向于遗传分层，但是这一过程是由地理分选或分类交配导致的，并且基因型是否可能由于非生殖性关联或其他过程而相关还不清楚。在这里，我们研究了来自青少年健康国家纵向研究的六种可用基因型，以测试朋友之间的遗传相似性。友谊网络的地图显示了基因型的聚类，并且在我们对种群分层进行严格控制之后，结果显示一种基因型是正相关的（同质性），而一种基因型是负相关的（异质性）。在Framingham心脏研究的独立样本中进行的复制研究验证了DRD2表现出显着的同质性，而CYP2A6表现出了显着的异质性。这些独特的结果表明，同质和异质在遗传（实际上是等位基因）水平上获得，这对研究群体遗传学和社会行为具有重要意义。尤其是，这些结果表明，关联测试应包括朋友的基因，而进化论则应考虑到这样一个事实，即从某种意义上讲，人类可能会对周围的人类具有宏基因组学意义。

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