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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Outcrossing, mitotic recombination, and life-history trade-offs shape genome evolution in Saccharomyces cerevisiae
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Outcrossing, mitotic recombination, and life-history trade-offs shape genome evolution in Saccharomyces cerevisiae

机译：酿酒酵母的杂交，有丝分裂重组和生活史权衡塑造基因组进化。

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摘要

We carried out a population genomic survey of Saccharomyces cerevisiae diploid isolates and find that many budding yeast strains have high levels of genomic heterozygosity, much of which is likely due to outcrossing. We demonstrate that variation in heterozygosity among strains is correlated with a life-history tradeoff that involves how readily yeast switch from asexual to sexual reproduction under nutrient stress. This trade-off is reflected in a negative relationship between sporulation efficiency and pseu-dohyphal development and correlates with variation in the expression of RME1, a transcription factor with pleiotropic effects on meiosis and filamentous growth. Selection for alternate life-history strategies in natural versus human-associated environments likely contributes to differential maintenance of genomic heterozygosity through its effect on the frequency that yeast lineages experience sexual cycles and hence the opportunity for in-breeding. In addition to elevated levels of heterozygosity, many strains exhibit large genomic regions of loss-of-heterozygosity (LOH), suggesting that mitotic recombination has a significant impact on genetic variation in this species. This study provides new insights into the roles that both outcrossing and mitotic recombination play in shaping the genome architecture of Saccharomyces cerevisiae. This study also provides a unique case where stark differences in the genomic distribution of genetic variation among individuals of the same species can be largely explained by a life-history trade-off.
机译：我们进行了酿酒酵母二倍体分离株的群体基因组研究，发现许多出芽的酵母菌株具有高水平的基因组杂合性，其中很大一部分可能是由于杂交。我们证明，菌株之间杂合性的变异与生活史的权衡有关，后者涉及在营养胁迫下酵母如何容易地从无性繁殖转变为有性繁殖。这种权衡反映在孢子形成效率与假单孢菌发育之间的负相关关系中，并与RME1表达的变化相关，RME1是对减数分裂和丝状生长具有多效性的转录因子。在自然环境与人类相关环境中选择其他生命史策略可能会通过影响酵母谱系经历性周期的频率以及近亲繁殖机会而有助于基因组杂合性的差异性维持。除了杂合性水平升高外，许多菌株还表现出大的杂合子丢失基因组区域（LOH），这表明有丝分裂重组对该物种的遗传变异具有重要影响。这项研究提供了新的见解，以交叉和有丝分裂重组在塑造酿酒酵母的基因组结构中发挥的作用。这项研究还提供了一个独特的案例，即在同一物种的个体之间遗传变异的基因组分布的明显差异在很大程度上可以通过生命历史权衡来解释。

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    Paul M. Magwene; OEmuer Kay(i)kc(i); Joshua A. Granek; Jennifer M. Reininga; Zackary Scholl; Debra Murray;

  • 作者单位

    Department of Biology and Institute for Genome Sciences and Policy Center for Systems Biology, Duke University, Durham, NC 27708;

    Department of Biology and Institute for Genome Sciences and Policy Center for Systems Biology, Duke University, Durham, NC 27708;

    Department of Biology and Institute for Genome Sciences and Policy Center for Systems Biology, Duke University, Durham, NC 27708;

    Department of Biology and Institute for Genome Sciences and Policy Center for Systems Biology, Duke University, Durham, NC 27708;

    Department of Biology and Institute for Genome Sciences and Policy Center for Systems Biology, Duke University, Durham, NC 27708;

    Department of Biology and Institute for Genome Sciences and Policy Center for Systems Biology, Duke University, Durham, NC 27708;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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