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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Urml couples sulfur transfer to ubiquitin-like protein function in oxidative stress
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Urml couples sulfur transfer to ubiquitin-like protein function in oxidative stress

机译：Urml将硫转移耦合至氧化应激中的泛素样蛋白功能

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摘要

The posttranslational modification of proteins with ubiquitin and ubiquitin-like proteins (collectively referred to as UBLs) has emerged as a major regulatory mechanism in eukaryotes. UBLs are characterized by a core (3-grasp fold and an essential car-boxy terminal glycine within a di-glycine motif (1). These features are also found in several prokaryotic sulfur carriers, suggestive of an evolutionary relationship to UBLs (2-5). A case in point is the UBL Urml (ubiquitin-related modifier 1). Urml is known to be conjugated to the peroxiredoxin Ahpl (6), but its sequence and structure more closely resembles bacterial sulfur carrier proteins (7). In PNAS, work by Van der Veen et al. provides important insight into the mechanism of Urml conjugation that highlights its position as an ancient UBL in eukaryotes and solidifies its roles as a posttranslational protein modifier involved in oxidative stress response mechanisms (8).
机译：用泛素和泛素样蛋白（统称为UBL）对蛋白进行翻译后修饰已成为真核生物的主要调控机制。 UBLs的特征是核心（3倍折叠和双甘氨酸基序内必不可少的羧基末端甘氨酸（1）。在一些原核硫载体中也发现了这些特征，暗示了与UBLs的进化关系（2- 5）。一个典型的例子是UBL Urml（泛素相关的修饰物1），已知Urml与过氧化物酶Ahpl结合（6），但其序列和结构更类似于细菌硫载体蛋白（7）。 Van der Veen等人的PNAS提供了关于Urml共轭机制的重要见解，突出了其在真核生物中作为古老UBL的地位，并巩固了其作为参与氧化应激反应机制的翻译后蛋白质修饰剂的作用（8）。

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    Matthew D. Petroski; Guy S. Salvesen; Dieter A. Wolf;

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    Signal Transduction Program,Sanford-Burnham Medical Research Institute,La Jolla, CA 92037;

    Program in Apoptosis and Cell Death Research,Sanford-Burnham Medical Research Institute,La Jolla, CA 92037;

    Signal Transduction Program,Sanford-Burnham Medical Research Institute,La Jolla, CA 92037;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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