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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Plastid gene expression and plant development require a plastidic protein of the mitochondrial transcription termination factor family
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Plastid gene expression and plant development require a plastidic protein of the mitochondrial transcription termination factor family

机译：质体基因表达和植物发育需要线粒体转录终止因子家族的质体蛋白

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摘要

Plastids are DNA-containing organelles unique to plant cells. In Arabidopsis, one-third of the genes required for embryo development encode plastid-localized proteins. To help understand the role of plastids in embryogenesis and postembryonic development, we characterized proteins of the mitochondrial transcription termination factor (mTERF) family, which in animal models, comprises DNA-binding regulators of mitochondrial transcription. Of 35 Arabidopsis mTERF proteins, 11 are plastid-localized. Genetic complementation shows that at least one plastidic mTERF, BELAYA SMERT' (BSM), is required for embryogenesis. The main postembryonic phenotypes of genetic mosaics with the bsm mutation are severe abnormalities in leaf development. Mutant bsm cells are albino, are compromised in growth, and suffer defects in global plastidic gene expression. The bsm phenotype could be phenocopied by inhibition of plastid translation with spectinomy-cin. Plastid translation is essential for cell viability in dicotyledonous species such as tobacco but not in monocotyledonous maize. Here, genetic interactions between BSM and the gene encoding plastid homomeric acetyl-CoA carboxylase ACC2 suggest that there is a functional redundancy in malonyl-CoA biosynthesis that permits bsm cell survival in Arabidopsis. Overall, our results indicate that biosynthesis of malonyl-CoA and plastid-derived systemic growth-promoting compounds are the processes that link plant development and plastid gene expression.
机译：质体是植物细胞特有的含DNA的细胞器。在拟南芥中，胚胎发育所需基因的三分之一编码质体定位蛋白。为了帮助理解质体在胚胎发生和胚胎后发育中的作用，我们对线粒体转录终止因子（mTERF）家族的蛋白质进行了表征，该蛋白在动物模型中包含线粒体转录的DNA结合调节剂。在35种拟南芥mTERF蛋白中，有11种是质体定位的。遗传互补显示胚胎发生至少需要一种质体mTERF，即BELAYA SMERT'（BSM）。具有bsm突变的遗传花叶的胚后主要表型是叶片发育中的严重异常。突变的bsm细胞是白化病，生长受到损害，并且在整体质体基因表达中存在缺陷。 bsm表型可以通过用壮观霉素抑制质体翻译来表型化。质体翻译对于双子叶植物（例如烟草）中的细胞活力至关重要，但对单子叶玉米而言则不是。在这里，BSM和编码质体同质乙酰辅酶A羧化酶ACC2的基因之间的遗传相互作用表明丙二酰辅酶A生物合成中存在功能冗余，可以使拟南芥中的bsm细胞存活。总体而言，我们的结果表明，丙二酰辅酶A和质体衍生的系统性生长促进化合物的生物合成是将植物发育与质体基因表达联系起来的过程。

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    Elena Babiychuk; Klaas Vandepoele; Josef Wissing; Miguel Garcia-Diaz; Riet De Rycke; Hana Akbari; Jerome Joubes; Tom Beeckman; Lothar Jaensch; Margrit Frentzen; Marc C. E. Van Montagu; Sergei Kushnir;

  • 作者单位

    Department of Plant Systems Biology, VIB, 9052 Ghent, Belgium,Department of Plant Bjotechnology and Genetics, Ghent University, 9052 Ghent, Belgium;

    Department of Plant Systems Biology, VIB, 9052 Ghent, Belgium,Department of Plant Bjotechnology and Genetics, Ghent University, 9052 Ghent, Belgium;

    Abteilung Zellbiologie, Helmholtz-Zentrum fur Infektionsforschung GmbH, 38124 Braunschweig, Germany;

    Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794-8651;

    Department of Plant Systems Biology, VIB, 9052 Ghent, Belgium,Department of Plant Bjotechnology and Genetics, Ghent University, 9052 Ghent, Belgium;

    lnstitut fur Biologie I, Spezielle Botanik, Rheinisch-Westfalische Technische Hochschule Aachen, 52056 Aachen,Germany;

    Universite Victor Segalen Bordeaux 2, Laboratoire de Biogenese Membranaire, Centre National de la Recherche Scientifique, 33076 Bordeaux Cedex, France;

    Department of Plant Systems Biology, VIB, 9052 Ghent, Belgium,Department of Plant Bjotechnology and Genetics, Ghent University, 9052 Ghent, Belgium;

    Abteilung Zellbiologie, Helmholtz-Zentrum fur Infektionsforschung GmbH, 38124 Braunschweig, Germany;

    lnstitut fur Biologie I, Spezielle Botanik, Rheinisch-Westfalische Technische Hochschule Aachen, 52056 Aachen,Germany;

    Department of Plant Bjotechnology and Genetics, Ghent University, 9052 Ghent, Belgium;

    Department of Plant Systems Biology, VIB, 9052 Ghent, Belgium,Department of Plant Bjotechnology and Genetics, Ghent University, 9052 Ghent, Belgium;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    organellar gene expression; splicing; cippr protease; myrosinase; digitonin;

    机译：细胞器基因表达;剪接;cippr蛋白酶;黑芥子酶;洋地黄皂苷;

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