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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >FLOWERING LOCUS C (FLC) regulates development pathways throughout the life cycle of Arabidopsis
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FLOWERING LOCUS C (FLC) regulates development pathways throughout the life cycle of Arabidopsis

机译：花地点C（FLC）调节拟南芥整个生命周期的发育途径

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摘要

FLOWERING LOCUS C (FLC) has a key role in the timing of the initiation of flowering in Arabidopsis. FLC binds and represses two genes that promote flowering, FT and SOC1. We show that FLC binds to many other genes, indicating that it has regulatory roles other than the repression of flowering. We identified 505 FLC binding sites, mostly located in the promoter regions of genes and containing at least one CArG box, the motif known to be associated with MADS-box proteins such as FLC. We examined 40 of the target genes, and 20 showed increased transcript levels in an flc mutant compared with the wild type. Five genes showed decreased expression in the mutant, indicating that FLC binding can result in either transcriptional repression or activation. The genes we identified as FLC targets are involved in developmental pathways throughout the life history of the plant, many of which are associated with reproductive development. FLC is also involved in vegetative development, as evidenced by its binding to SPL1S, delaying the progression from juvenile to adult phase. Some of the FLC target genes are also bound by two other MADS-box proteins, AP1 and SEP3, suggesting that MADS-box genes may operate in a network of control at different stages of the life cycle, many ultimately contributing to the development of the reproductive phase of the plant.
机译：在拟南芥中，开花的位置C（FLC）在开始开花的时间中起关键作用。 FLC结合并抑制两个促进开花的基因FT和SOC1。我们显示，FLC与许多其他基因结合，表明它具有调控作用，除了抑制开花。我们确定了505个FLC结合位点，主要位于基因的启动子区域，并包含至少一个CArG盒，CArG盒是已知与MADS-box蛋白（例如FLC）相关的基序。我们检查了40个目标基因，与野生型相比，flc突变体中有20个显示出更高的转录水平。五个基因在突变体中表达降低，表明FLC结合可导致转录抑制或激活。我们确定为FLC靶标的基因在植物的整个生命历史中都参与了发育途径，其中许多与生殖发育有关。 FLC还与植物生长有关，这通过与SPL1S结合而得以证明，从而延迟了从幼年阶段到成年阶段的发展。一些FLC靶基因还与另外两个MADS-box蛋白AP1和SEP3结合，这表明MADS-box基因可能在生命周期的不同阶段在控制网络中运作，许多最终促进了该基因的发展。植物的繁殖期。

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