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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Genome-wide nested association mapping of quantitative resistance to northern leaf blight in maize
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Genome-wide nested association mapping of quantitative resistance to northern leaf blight in maize

机译:玉米全基因组抗北枯萎病的全基因组嵌套关联图谱

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摘要

Quantitative resistance to plant pathogens, controlled by multiple loci of small effect, is important for food production, food security, and food safety but is poorly understood. To gain insights into the genetic architecture of quantitative resistance in maize, we evaluated a 5,000-inbred-line nested association mapping population for resistance to northern leaf blight, a maize disease of global economic importance. Twenty-nine quantitative trait loci were identified, and most had multiple alleles. The large variation in resistance pheno-types could be attributed to the accumulation of numerous loci of small additive effects. Genome-wide nested association mapping, using 1.6 million SNPs, identified multiple candidate genes related to plant defense, including receptor-like kinase genes similar to those involved in basal defense. These results are consistent with the hypothesis that quantitative disease resistance in plants is conditioned by a range of mechanisms and could have considerable mechanistic overlap with basal resistance.
机译:由多个位点控制的对植物病原体的定量抗性影响很小,对食品生产,食品安全和食品安全很重要,但了解甚少。为了深入了解玉米中定量抗性的遗传结构,我们评估了5000个近交系嵌套关联图谱种群对北方叶枯病(一种具有全球经济重要性的玉米疾病)的抗性。确定了29个数量性状基因座,并且大多数具有多个等位基因。耐药性表型的巨大差异可归因于大量小的累加效应基因座的积累。使用160万个SNP进行的全基因组巢式关联作图,鉴定了多个与植物防御相关的候选基因,包括与基础防御相关的类似于受体的激酶基因。这些结果与以下假设相吻合:植物中的定量抗病性受多种机制制约,并且可能与基础抗性具有相当大的机制重叠。

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