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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Changes in cortical interneuron migration contribute to the evolution of the neocortex
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Changes in cortical interneuron migration contribute to the evolution of the neocortex

机译：皮质神经元间迁移的变化有助于新皮质的进化

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The establishment of the mammalian neocortex is often explained phylogenetically by an evolutionary change in the pallial neuronal progenitors of excitatory projection neurons. It remains unclear, however, whether and how the evolutionary change in inhibitory interneurons, which originate outside the neocortex, has been involved in the establishment of the neocortex. In this study, we transplanted chicken, turtle, mouse, and marmoset medial gangli-onic eminence (MGE) cells into the embryonic mouse MGE in utero and compared their migratory behaviors. We found that the MGE cells from all of the species were able to migrate through the mouse neocortical subventricular zone and that both the mouse and marmoset cells subsequently invaded the neocortical cortical plate (CP). However, regardless of their birthdates and interneuron subtypes, most of the chicken and turtle cells ignored the neocortical CP and passed beneath it, although they were able to invade the archicortex and paleocortex, suggesting that the proper responsiveness of MGE cells to guidance cues to enter the neocortical CP is unique to mammals. When chicken MGE cells were transplanted directly into the neocortical CP, they were able to survive and mature, suggesting that the neocortical CP itself is essentially permissive for postmigratory development of chicken MGE cells. These results suggest that an evolutionary change in the migratory ability of inhibitory interneurons, which originate outside the neocortex, was involved in the establishment of the neocortex by supplying inhibitory components to the network.
机译：哺乳动物新皮层的建立通常在系统发育上通过兴奋性投射神经元的睑神经元祖细胞的进化变化来解释。然而，尚不清楚是否起源于新皮层之外的抑制性中间神经元的进化变化以及如何参与了新皮层的建立。在这项研究中，我们将鸡，乌龟，小鼠和mar猴的内侧神经节性隆起（MGE）细胞移植到子宫内的胚胎小鼠MGE中，并比较了它们的迁徙行为。我们发现，来自所有物种的MGE细胞都能够通过小鼠新皮层脑室下区迁移，并且小鼠和mar猴细胞随后都侵入了新皮层皮层板（CP）。然而，不管它们的出生日期和中间神经元亚型如何，大多数鸡和乌龟细胞都忽略了新皮层CP，并通过了它的下方，尽管它们能够侵入始皮层和古皮层，这表明MGE细胞对引导线索进入的正确反应新皮质CP是哺乳动物所独有的。将鸡MGE细胞直接移植到新皮层CP中后，它们能够存活并成熟，这表明新皮层CP本身实质上允许鸡MGE细胞的迁移后发育。这些结果表明，起源于新皮层之外的抑制性中间神经元迁移能力的进化变化通过向网络提供抑制成分而参与了新皮层的建立。

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