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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Drinking a hot blood meal elicits a protective heat shock response in mosquitoes
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Drinking a hot blood meal elicits a protective heat shock response in mosquitoes

机译:喝热血餐会引起蚊子的保护性热休克反应

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摘要

The mosquito's body temperature increases dramatically when it takes a blood meal from a warm-blooded, vertebrate host. By using the yellow fever mosquito, Aedes aegypti, we demonstrate that this boost in temperature following a blood meal prompts the synthesis of heat shock protein 70 (Hsp70). This response, elicited by the temperature of the blood meal, is most robust in the mosquito's midgut. When RNA interference is used to suppress expression of hsp70, protein digestion of the blood meal is impaired, leading to production of fewer eggs. We propose that Hsp70 protects the mosquito midgut from the temperature stress incurred by drinking a hot blood meal. Similar increases in hsp70 were documented immediately after blood feeding in two other mosquitoes (Culex pipiens and Anopheles gambiae) and the bed bug, Cimex lectularius, suggesting that this is a common protective response in blood-feeding arthropods.
机译:蚊子从温血的脊椎动物宿主身上取血后,其体温急剧上升。通过使用黄热病蚊子埃及伊蚊,我们证明了血餐后温度的升高提示了热激蛋白70(Hsp70)的合成。血粉温度引起的这种反应在蚊子的中肠中最为强烈。当使用RNA干扰抑制hsp70的表达时,血粉的蛋白质消化会受到损害,从而导致卵的产生减少。我们建议Hsp70保护蚊子中肠免受因喝热血粉引起的温度压力。在另外两个蚊子(淡色库蚊和冈比亚按蚊)和臭虫Cimex lectularius吸血后,hsp70的升高也有类似的增加,这表明这是在采血节肢动物中常见的保护性反应。

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    Departments of Entomology and Evolution, Ecology and Organismal Biology, The Ohio State University, Columbus, OH 43210,Division of Epidemiology of Microbial Diseases, School of Public Health, Yale University, New Haven, CT 06510;

    Departments of Entomology and Evolution, Ecology and Organismal Biology, The Ohio State University, Columbus, OH 43210,Department of Entomology and Nematology, University of Florida,Gainesville, FL 32611;

    Departments of Entomology and Evolution, Ecology and Organismal Biology, The Ohio State University, Columbus, OH 43210;

    Departments of Entomology and Evolution, Ecology and Organismal Biology, The Ohio State University, Columbus, OH 43210;

    Departments of Entomology and Evolution, Ecology and Organismal Biology, The Ohio State University, Columbus, OH 43210;

    Departments of Entomology and Evolution, Ecology and Organismal Biology, The Ohio State University, Columbus, OH 43210;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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