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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Age-related memory deficits linked to circuit-specificdisruptions in the hippocampus
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Age-related memory deficits linked to circuit-specificdisruptions in the hippocampus

机译:与年龄相关的记忆缺陷与海马的电路特异性破坏有关

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摘要

Converging data from rodents and humans have demonstrated an age-related decline in pattern separation abilities (the ability to discriminate among similar experiences). Several studies have proposed the dentate and CA3 subfields of the hippocampus as the potential locus of this change. Specifically, these studies identified rigidity in place cell remapping in similar environments in the CA3. We used high-resolution fMRI to examine activity profiles in the dentate gyrus and CA3 in young and older adults as stimulus similarity was incrementally varied. We report evidence for "representational rigidity" in older adults' dentate/CA3 that is linked to behavioral discrimination deficits. Using ultrahigh-resolution diffusion imaging, we quantified both the integrity of the perforant path as well as dentate/CA3 dendritic changes and found that both were correlated with dentate/CA3 functional rigidity. These results highlight structural and functional alterations in the hippocampal network that predict age-related changes in memory function and present potential targets for intervention.
机译:来自啮齿动物和人类的数据汇总表明,与年龄相关的模式分离能力(区分相似经历的能力)下降。几项研究提出了海马的齿状和CA3子域作为这种变化的潜在场所。具体而言,这些研究确定了CA3中相似环境中原位细胞重映射的刚性。我们使用高分辨率的功能磁共振成像检查年轻人和老年人的齿状回和CA3的活动情况,因为刺激相似性逐渐变化。我们报告的证据表明,老年人的牙齿/ CA3中的“代表刚性”与行为歧视缺陷有关。使用超高分辨率扩散成像,我们量化了穿孔路径的完整性以及齿状/ CA3树突状变化,并发现两者均与齿状/ CA3功能刚性相关。这些结果突出了海马网络中的结构和功能变化,这些变化预测了记忆功能与年龄相关的变化,并提出了潜在的干预目标。

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  • 作者单位

    Department of Psychological and Brain Sciences, The Johns Hopkins University, Baltimore, MD 21218 Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 Center for Neurobiology of Learning and Memory, Irvine, CA 92697;

    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 Center for Neurobiology of Learning and Memory, Irvine, CA 92697;

    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 Center for Neurobiology of Learning and Memory, Irvine, CA 92697;

    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 Center for Neurobiology of Learning and Memory, Irvine, CA 92697;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    medial temporal lobe; diffusion tensor imaging; functional mri; generalization; pattern completion;

    机译:颞中叶;弥散张量成像;功能性MRI;全身化;模式完成;

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