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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Adaptation-induced synchronization in laminar cortical circuits
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Adaptation-induced synchronization in laminar cortical circuits

机译：层状皮层回路中的适应性诱导同步

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摘要

A fundamental feature of information processing in neocortex is the ability of individual neurons to adapt to changes in incoming stimuli. It is increasingly being understood that cortical adaptation is a phenomenon that requires network interactions. The fact that the structure of local networks depends critically on cortical layer raises the possibility that adaptation could induce specific effects in different layers. Here we show that brief exposure (300 ms) to a stimulus of fixed orientation modulates the strength of synchronization between individual neurons and local population activity in the gamma-band frequency (30-80 Hz) in macaque primary visual cortex (V1) and influences the ability of individual neurons to encode stimulus orientation. Using laminar probes, we found that although stimulus presentation elicits a large increase in the gamma synchronization of rhythmic neuronal activity in the input (granular) layers of V1, adaptation caused a pronounced increase in synchronization in the cortical output (supragranular) layers. The increase in gamma synchronization after adaptation was significantly correlated with an improvement in neuronal orientation discrimination performance only in the supragranular layers. Thus, synchronization between the spiking activity of individual neurons and their local population may enhance sensory coding to optimize network processing across laminar circuits.
机译：新皮层中信息处理的基本特征是单个神经元适应传入刺激变化的能力。越来越多地理解皮质适应是需要网络相互作用的现象。本地网络的结构严重依赖皮层的事实增加了适应可能在不同层中引起特定影响的可能性。在这里，我们表明，短时曝光（300毫秒）对固定方向的刺激会调节猕猴初级视觉皮层（V1）的伽马频带频率（30-80 Hz）中单个神经元与局部种群活动之间的同步强度。单个神经元编码刺激方向的能力。使用层状探针，我们发现，尽管刺激呈现在V1的输入（颗粒）层中引起节律性神经元活动的伽马同步大大增加，但适应引起了皮质输出（颗粒上）层中同步的明显增加。适应后伽马同步的增加与仅在颗粒上层中神经元定向识别性能的改善显着相关。因此，单个神经元的尖峰活动与其本地种群之间的同步可以增强感官编码，从而优化跨层流回路的网络处理。

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    Bryan J. Hansen; Valentin Dragoi;

  • 作者单位

    The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030;

    The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030,Department of Neurobiology and Anatomy, University of Texas-Houston Medical School, Houston, TX 77030;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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