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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform
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Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

机译：红细胞膜伪装的聚合物纳米颗粒作为仿生传递平台

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摘要

Efforts to extend nanoparticle residence time in vivo have inspired many strategies in particle surface modifications to bypass macro phage uptake and systemic clearance. Here we report a top-down biomimetic approach in particle functionalization by coating biode gradable polymeric nanoparticles with natural erythrocyte mem branes, including both membrane lipids and associated membrane proteins for long-circulating cargo delivery. The structure, size and surface zeta potential, and protein contents of the erythrocyte membrane-coated nanoparticles were verified using transmission electron microscopy, dynamic light scattering, and gel electrophor esis, respectively. Mice injections with fluorophore-loaded nano particles revealed superior circulation half-life by the erythrocyte mimicking nanoparticles as compared to control particles coated with the state-of-the-art synthetic stealth materials. Biodistribu tion study revealed significant particle retention in the blood 72 h following the particle injection. The translocation of natural cellu lar membranes, their associated proteins, and the corresponding functionalities to the surface of synthetic particles represents a unique approach in nanoparticle functionalization.
机译：延长体内纳米粒子停留时间的努力激发了许多粒子表面修饰的策略，以绕过巨噬细胞的摄取和系统清除。在这里，我们报告了一种通过在生物功能可分级聚合的纳米颗粒上覆盖天然红细胞膜（包括膜脂和相关膜蛋白，用于长循环货物运输）在生物功能可降解聚合物纳米颗粒上进行颗粒化功能的自顶向下仿生方法。分别使用透射电子显微镜，动态光散射和凝胶电泳验证了红细胞膜包被的纳米颗粒的结构，大小和表面zeta电位以及蛋白质含量。与涂有最新技术的合成隐形材料的对照颗粒相比，用荧光团负载的纳米颗粒进行的小鼠注射显示出通过模仿红细胞的纳米颗粒具有更好的循环半衰期。生物分布研究表明，注射颗粒后72小时，血液中的颗粒明显滞留。天然纤维素膜，其相关蛋白以及相应功能向合成颗粒表面的移位代表了纳米颗粒功能化的独特方法。

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  • 作者

    Che-Ming J. Hu; Li Zhang; Santosh Aryal; Connie Cheung; Ronnie H. Fang; Liangfang Zhang;

  • 作者单位

    Department of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093;

    Department of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093;

    Department of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093;

    Department of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093;

    Department of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093;

    Department of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    biomimetic nanoparticle; drug delivery; long circulation; red blood cell membrane;

    机译：仿生纳米颗粒;药物输送;长循环;红细胞膜;

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