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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Related pituitary cell lineages develop into interdigitated 3D cell networks
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Related pituitary cell lineages develop into interdigitated 3D cell networks

机译：相关垂体细胞谱系发展成指状3D细胞网络

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摘要

The pituitary gland has long been considered to be a random patchwork of hormone-producing cells. By using pituitary-scale tridimensional imaging for two of the least abundant cell lineages, the corticotropes and gonadotropes, we have now uncovered highly organized and interdigitated cell networks that reflect homotypic and heterotypic interactions between cells. Although newly differentiated corticotrope cells appear on the ventral surface of the gland, they rapidly form homotypic strands of cells that extend from the lateral tips of the anterior pituitary along its ventral surface and into the medial gland. As the corticotrope network is established away from the microvasculature, cell morphology changes from rounded, to polygonal, and finally to cells with long cytoplasmic processes or cytonemes that connect corticotropes to the perivascular space. Gonadotropes differentiate later and are positioned in close proximity to corticotropes and capillaries. Blockade of corticotrope terminal differentiation produced by knockout of the gene encoding the transcription factor Tpit results in smaller gonadotropes within an expanded cell network, particularly in the lateral gland. Thus, pituitary-scale tridimensional imaging reveals highly structured cell networks of unique topology for each pituitary lineage. The sequential development of interdigitated cell networks during organogenesis indicate that extensive cellxell interactions lead to a highly ordered cell positioning rather than random patchwork.
机译：垂体长期以来被认为是激素产生细胞的随机拼凑。通过对两个最不丰富的细胞谱系（促肾上腺皮质激素和促性腺激素）使用垂体尺度的三维成像技术，我们现在发现了反映细胞之间同型和异型相互作用的高度组织化和交叉指状的细胞网络。尽管新分化的皮质激素细胞出现在腺体的腹表面，但它们迅速形成同型细胞链，这些细胞从垂体前叶的外侧末端沿腹膜的腹表面延伸到内侧腺体。随着皮质激素网络的建立远离微血管，细胞形态会从圆形变为多边形，最后变为具有长胞质过程或细胞激素的细胞，这些细胞质或细胞因子将促肾上腺皮质激素连接到血管周围空间。促性腺激素分化较晚，并位于皮质激素和毛细血管附近。通过敲除编码转录因子Tpit的基因而产生的皮质激素终末分化的阻断导致在扩大的细胞网络内，特别是在外侧腺体中的较小的促性腺激素。因此，垂体尺度的三维成像揭示了每个垂体谱系独特拓扑的高度结构化的细胞网络。在器官发生过程中交叉指状细胞网络的顺序发展表明，广泛的细胞相互作用会导致高度有序的细胞定位，而不是随机的拼凑。

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  • 作者

    Lionel Budry; Chrystel Lafont; Taoufik El Yandouzi; Norbert Chauvet; Genevieve Conejero; Jacques Drouin; Patrice Mollard;

  • 作者单位

    Laboratory of Molecular Genetics, Instltut de Recherches Cliniques de Montreal, Montreal, QC, Canada H2W 1R7;

    Department of Endocrinology, Institute of Functional Genomics, 34094 Montpellier, France,Centre National de la Recherche Scientifique Unite Mixte de Recherche 5203,lnstitut National de la Sante et de la Recherche Medicale U661, 34094 Montpellier, France,Universite de Montpellier, 34094 Montpellier, France;

    Department of Endocrinology, Institute of Functional Genomics, 34094 Montpellier, France,Centre National de la Recherche Scientifique Unite Mixte de Recherche 5203,lnstitut National de la Sante et de la Recherche Medicale U661, 34094 Montpellier, France,Universite de Montpellier, 34094 Montpellier, France;

    Department of Endocrinology, Institute of Functional Genomics, 34094 Montpellier, France,Centre National de la Recherche Scientifique Unite Mixte de Recherche 5203,lnstitut National de la Sante et de la Recherche Medicale U661, 34094 Montpellier, France,Universite de Montpellier, 34094 Montpellier, France;

    lnstitut National de la Recherche Agronomique,Unite Mixte de Recherche Biochimie et Physiologie Moleculaire des Plantes, 34060 Montpellier, France;

    Laboratory of Molecular Genetics, Instltut de Recherches Cliniques de Montreal, Montreal, QC, Canada H2W 1R7;

    Department of Endocrinology, Institute of Functional Genomics, 34094 Montpellier, France,Centre National de la Recherche Scientifique Unite Mixte de Recherche 5203,lnstitut National de la Sante et de la Recherche Medicale U661, 34094 Montpellier, France,Universite de Montpellier, 34094 Montpellier, France;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    reproduction-1 stress; systems biology; pro-opiomelanocortin; gonadotropins;

    机译：生殖1胁迫;系统生物学;促黑素皮质素;促性腺激素;

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