...
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Systemic augmentation of αB-crystallin provides therapeutic benefit twelve hours post-stroke onset via immune modulation
【24h】

Systemic augmentation of αB-crystallin provides therapeutic benefit twelve hours post-stroke onset via immune modulation

机译:脑卒中发作后十二小时,通过免疫调节全身增强αB-晶状体蛋白可提供治疗益处

获取原文
获取原文并翻译 | 示例
           

摘要

Tissue plasminogen activator is the only treatment option for stroke victims; however, it has to be administered within 4.5 h after symptom onset, making its use very limited. This report describes a unique target for effective treatment of stroke, even 12 h after onset, by the administration of ocB-crystallin (Cryab), an endogenous immunomodulatory neuroprotectant. In Cxyab~'~ mice, there was increased lesion size and diminished neurologic function after stroke compared with wild-type mice. Increased plasma Cryab was detected after experimental stroke in mice and after stroke in human patients. Administration of Cryab even 12 h after experimental stroke reduced both stroke volume and inflammatory cytokines associated with stroke pathology. Cryab is an endogenous anti-inflammatory and neuroprotectant molecule produced after stroke, whose beneficial properties can be augmented when administered therapeutically after stroke.
机译:组织纤溶酶原激活剂是中风患者的唯一治疗选择。但是,它必须在症状发作后4.5小时内服用,这使其使用非常有限。该报告描述了通过给予内源性免疫调节神经保护剂ocB-crystallin(Cryab)甚至在发病后12小时即可有效治疗中风的独特靶标。与野生型小鼠相比,中风后Cxyab-/-小鼠具有更大的病变大小和神经功能减弱。在小鼠实验性中风后和人类患者中风后检测到血浆Cryab升高。实验性卒中后甚至在12小时后给予Cryab均可减少卒中量和与卒中病理相关的炎性细胞因子。 Cryab是中风后产生的内源性抗炎和神经保护分子,当在中风后进行治疗性给药时,其有益特性可以增强。

著录项

  • 来源
  • 作者单位

    Department of Neurosurgery,Stanford, CA 94305,Stanford Institute for Neuro-lnnovation and Translational Neurosciences Stanford, CA 94305,Stanford Stroke Center,Stanford, CA 94305;

    Stanford Institute for Neuro-lnnovation and Translational Neurosciences Stanford, CA 94305,Departments of Biology, Stanford, CA 94305,Neurology and Neurological Sciences Stanford, CA 94305;

    Medicine, Stanford University School of Medicine, Stanford, CA 94305;

    Stanford Institute for Neuro-lnnovation and Translational Neurosciences Stanford, CA 94305,Stanford Stroke Center,Stanford, CA 94305,Neurology and Neurological Sciences Stanford, CA 94305;

    Medicine, Stanford University School of Medicine, Stanford, CA 94305;

    Department of Neurosurgery,Stanford, CA 94305,Stanford Institute for Neuro-lnnovation and Translational Neurosciences Stanford, CA 94305,Stanford Stroke Center,Stanford, CA 94305;

    Stanford Institute for Neuro-lnnovation and Translational Neurosciences Stanford, CA 94305,Stanford Stroke Center,Stanford, CA 94305,Neurology and Neurological Sciences Stanford, CA 94305;

    Stanford Institute for Neuro-lnnovation and Translational Neurosciences Stanford, CA 94305,Departments of Biology, Stanford, CA 94305;

    Department of Neurosurgery,Stanford, CA 94305,Stanford Institute for Neuro-lnnovation and Translational Neurosciences Stanford, CA 94305,Stanford Stroke Center,Stanford, CA 94305;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    immune system; ischemic stroke;

    机译:免疫系统;缺血性中风;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号