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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF)
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The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF)

机译:D-dopachrome互变异构酶(DDT)基因产物是巨噬细胞迁移抑制因子(MIF)的细胞因子和功能同源物

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摘要

The therapeutic targeting of immunologic hormones or cyto-kines has shown clinical success in the treatment of chronic inflammatory diseases. A proin-flammatory cytokine known as macrophage migration inhibitory factor (MIF) functions upstream in the inflammatory cascade and is considered a promising therapeutic target for rheumatoid arthritis (1). Inflammatory or invasive stimuli trigger the rapid release of MIF from immune cells; MIF then acts to promote immune cell activation and survival, and it enables the maximum production of downstream inflammatory mediators (2).
机译:免疫激素或细胞因子的治疗靶向已显示出在治疗慢性炎性疾病方面的临床成功。一种被称为巨噬细胞迁移抑制因子(MIF)的促炎性细胞因子在炎症级联反应的上游起作用,被认为是类风湿关节炎的有希望的治疗靶点(1)。炎性或侵入性刺激触发MIF从免疫细胞中快速释放。然后,MIF起到促进免疫细胞活化和存活的作用,并能最大程度地产生下游炎症介质(2)。

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    Departments of Internal Medicine, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520,lnstitute of Biochemistry and Molecular Cell Biology, Rheinisch Westfaelische Technische Hochschule, 52074 Aachen, Germany,Division of Clinical Pharmacology, Ludwig-Maximilian University, 80336 Munich, Germany;

    Departments of Pharmacology, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520;

    Departments of Internal Medicine, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520;

    Departments of Internal Medicine, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520;

    Departments of Internal Medicine, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520;

    Departments of Internal Medicine, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520,lnstitute of Biochemistry and Molecular Cell Biology, Rheinisch Westfaelische Technische Hochschule, 52074 Aachen, Germany;

    Departments of Internal Medicine, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520;

    lnstitute of Biochemistry and Molecular Cell Biology, Rheinisch Westfaelische Technische Hochschule, 52074 Aachen, Germany;

    Department of Clinical Immunology, Mt. Sinai School of Medicine, New York, NY 10029;

    Department of Clinical Immunology, Mt. Sinai School of Medicine, New York, NY 10029;

    Department of Pediatrics, University of Sherbrooke, Sherbrooke, QC, Canada J1H 5N4;

    lnstitute of Biochemistry and Molecular Cell Biology, Rheinisch Westfaelische Technische Hochschule, 52074 Aachen, Germany;

    Departments of Pharmacology, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520;

    Departments of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven CT 06520;

    Department of Pediatrics, University of Sherbrooke, Sherbrooke, QC, Canada J1H 5N4;

    Departments of Internal Medicine, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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