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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Spatiotemporal regulation of chemical reactions by active cytoskeletal remodeling
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Spatiotemporal regulation of chemical reactions by active cytoskeletal remodeling

机译：通过主动的细胞骨架重塑对化学反应的时空调节

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摘要

Efficient and reproducible construction of signaling and sorting complexes, both on the surface and within the living cell, is contingent on local regulation of biochemical reactions by the cellular milieu. We propose that in many cases this spatiotemporal regulation can be mediated by interaction with components of the dynamic cytoskeleton. We show how the interplay between active contractility and remodeling of the cytoskeleton can result in transient focusing of passive molecules to form clusters, leading to a dramatic increase in the reaction efficiency and output levels. The dynamic cytoskeletal elements that drive focusing behave as quasienzymes catalyzing the chemical reaction. These ideas are directly applicable to the cortical actin-dependent clustering of cell surface proteins such as lipid-tethered GPI-anchored proteins, Ras proteins, as well as many proteins that have domains that confer the ability to interact with the actin cytoskeleton. In general such cytoskeletal driven clustering of proteins could be a cellular mechanism to spatiotemporally regulate and amplify local chemical reaction rates in a variety of contexts such as signaling, transcription, sorting, and endocytosis.
机译：信号和分选复合物在表面和活细胞内的有效且可再现的构建取决于细胞环境对生化反应的局部调节。我们建议在许多情况下可以通过与动态细胞骨架成分的相互作用来介导这种时空调节。我们展示了主动收缩力与细胞骨架重塑之间的相互作用如何导致被动分子瞬时聚焦形成簇，从而导致反应效率和输出水平急剧提高。驱动聚焦的动态细胞骨架元素表现为催化化学反应的拟酶。这些想法直接适用于细胞表面蛋白的皮质肌动蛋白依赖性簇，例如脂质连接的GPI锚定蛋白，Ras蛋白以及许多具有赋予与肌动蛋白细胞骨架相互作用能力的结构域的蛋白。通常，这种细胞骨架驱动的蛋白质簇可以是在多种情况下（例如信号传导，转录，分选和内吞作用）时空调节和放大局部化学反应速率的细胞机制。

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  • 作者

    Abhishek Chaudhuri; Bhaswati Bhattacharya; Kripa Gowrishankar; Satyajit Mayor; Madan Rao;

  • 作者单位

    Raman Research Institute, C. V. Raman Avenue, Bangalore 560080, India,Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, United Kingdom,The Rudolf Peierls Centre for Theoretical Physics, University of Oxford, Oxford 0X1 3NP, United Kingdom;

    Theoretical Studies Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur Campus, Bangalore 560080, India;

    Raman Research Institute, C. V. Raman Avenue, Bangalore 560080, India,National Centre for Biological Sciences (TIFR), Bellary Road, Bangalore 560065, India;

    National Centre for Biological Sciences (TIFR), Bellary Road, Bangalore 560065, India;

    Raman Research Institute, C. V. Raman Avenue, Bangalore 560080, India,National Centre for Biological Sciences (TIFR), Bellary Road, Bangalore 560065, India;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    active hydrodynamics; signal transduction;

    机译：主动流体力学信号转导;

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