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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Role of stochastic processes in maintaining discrete strain structure in antigenically diverse pathogen populations
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Role of stochastic processes in maintaining discrete strain structure in antigenically diverse pathogen populations

机译：随机过程在维持抗原多样性病原体种群中离散菌株结构中的作用

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摘要

Many highly diverse pathogen populations appear to exist stably as discrete antigenic types despite evidence of genetic exchange. It has been shown that this may arise as a consequence of immune selection on pathogen populations, causing them to segregate permanently into discrete nonoverlapping subsets of antigenic variants to minimize competition for available hosts. However, discrete antigenic strain structure tends to break down under conditions where there are unequal numbers of allelic variants at each locus. Here, we show that the inclusion of stochastic processes can lead to the stable recovery of discrete strain structure • through loss of certain alleles. This explains how pathogen populations may continue to behave as independently transmitted strains despite inevitable asymmetries in allelic diversity of major antigens. We present evidence for this type of structuring across global meningococcal isolates in three diverse antigens that are currently being developed as vaccine components.
机译：尽管有遗传交换的证据，许多高度多样化的病原体种群似乎以离散的抗原类型稳定存在。已经表明，这可能是由于对病原体群体进行免疫选择而导致的，导致它们永久性地分离成抗原变体的离散的非重叠子集，以最大程度地减少对可用宿主的竞争。但是，在每个位点存在等位基因变体数目不相等的条件下，离散的抗原菌株结构往往会崩溃。在这里，我们表明随机过程的包含可以通过丢失某些等位基因而导致离散菌株结构的稳定恢复。这解释了尽管主要抗原的等位基因多样性不可避免地存在不对称性，但病原体种群如何继续表现为独立传播的菌株。我们提供了目前正在开发为疫苗成分的三种不同抗原中跨全球脑膜炎球菌分离株的这种结构类型的证据。

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