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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Formation of plant metabolic gene clusters within dynamic chromosomal regions
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Formation of plant metabolic gene clusters within dynamic chromosomal regions

机译：在动态染色体区域内植物代谢基因簇的形成

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摘要

In bacteria, genes with related functions often are grouped together in operons and are cotranscribed as a single polycistronic mRNA. In eukaryotes, functionally related genes generally are scattered across the genome. Notable exceptions include gene clusters for catabolic pathways in yeast, synthesis of secondary metabolites in filamentous fungi, and the major histocompatibility complex in animals. Until quite recently it was thought that gene clusters in plants were restricted to tandem duplicates (for example, arrays of leucine-rich repeat disease-resistance genes). However, operon-like clusters of coregulated nonhomologous genes are an emerging theme in plant biology, where they may be involved in the synthesis of certain defense compounds. These clusters are unlikely to have arisen by horizontal gene transfer, and the mechanisms behind their formation are poorly understood. Previously in thale cress (Arabidopsis thaliana) we identified an operon-like gene cluster that is required for the synthesis and modification of the triterpene thalianol. Here we characterize a second operon-like triterpene cluster (the marneral cluster) from A. thaliana, compare the features of these two clusters, and investigate the evolutionary events that have led to cluster formation. We conclude that common mechanisms are likely to underlie the assembly and control of operon-like gene clusters in plants.
机译：在细菌中，具有相关功能的基因通常在操纵子中分组在一起，并共同转录为单个多顺反子mRNA。在真核生物中，功能相关的基因通常分散在整个基因组中。值得注意的例外包括酵母中分解代谢途径的基因簇，丝状真菌中次生代谢产物的合成以及动物的主要组织相容性复合体。直到最近，人们还认为植物中的基因簇仅限于串联重复（例如，富含亮氨酸的重复疾病抗性基因的阵列）。然而，有核心调控的非同源基因的类似操纵子的簇是植物生物学中的新兴主题，它们可能参与某些防御化合物的合成。这些簇不太可能是由水平基因转移引起的，对其形成背后的机理了解甚少。以前，在拟南芥（Arabidopsis thaliana）中，我们鉴定出了一种类似三萜萜烯醇的合成和修饰所需的操纵子样基因簇。在这里，我们表征了拟南芥的第二个类似操纵子的三萜簇（边际簇），比较了这两个簇的特征，并研究了导致簇形成的进化事件。我们得出结论，常见机制可能是植物中操纵子样基因簇的组装和控制的基础。

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  • 作者

    Ben Field; Anna-Sophie Fiston-Lavier; Ariane Kemen; Katrin Geisler; Hadi Quesneville; Anne E. Osbourn;

  • 作者单位

    Department of Metabolic Biology, John Innes Centre, Norwich NR4 7UH, United Kingdom,Laboratoire de Genetique et de Biophysique des Plantes (LGBP), Unite Mixte de Recherche 6191 Centre National de la Recherche Scientifique-Commissariat a I'Energie Atomique et aux Energies Alternatives-Universite de la Mediterranee, 13009 Marseille, France;

    Department of Biology, Stanford University, Stanford, CA 94305,Institut National de la Recherche Agronomique Centre de Versailles, Versailles 78026, France;

    Department of Metabolic Biology, John Innes Centre, Norwich NR4 7UH, United Kingdom;

    Department of Metabolic Biology, John Innes Centre, Norwich NR4 7UH, United Kingdom;

    Institut National de la Recherche Agronomique Centre de Versailles, Versailles 78026, France;

    Department of Metabolic Biology, John Innes Centre, Norwich NR4 7UH, United Kingdom;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    genome dynamics; metabolic diversification; chromatin;

    机译：基因组动力学;代谢多样化;染色质;

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