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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Cellular correlate of assembly formation in oscillating hippocampal networks in vitro
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Cellular correlate of assembly formation in oscillating hippocampal networks in vitro

机译:体外振荡海马网络中组装形成的细胞相关性

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摘要

How does the vast number of neurons in the brain enable highly reproducible actions such as coordinated movements, correct perception of relevant object features, or reliable memories? It has been suggested that neuronal networks include groups of highly interconnected neurons, which, on partial activation, recruit each other into stable activity patterns. Such neuronal assemblies may form the neuronal basis of memories. It is, however, unknown how neurons know whether they are part of a given assembly. We have studied this question in a model of sharp wave-ripple complexes (SPW-Rs), a well-delineated pattern of network activity in the mammalian hippocampal formation (Fig. PI A and B), which is a brain region implicated in learning and memory.
机译:大脑中大量的神经元如何实现高度可复制的动作,例如协调运动,对相关物体特征的正确感知或可靠的记忆?已经提出,神经元网络包括高度互连的神经元组,这些神经元在部分激活时彼此募集成稳定的活动模式。这样的神经元集合可以形成记忆的神经元基础。但是,尚不清楚神经元如何知道它们是否是给定装配的一部分。我们在尖波波纹复合体(SPW-Rs)模型中研究了这个问题,该模型是哺乳动物海马结构中网络活动的清晰描绘模式(图PIA和B),这是一个涉及学习的大脑区域和记忆。

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    Institute of Physiology and Pathophysiology, Medical Faculty, University of Heidelberg, D-69120 Heidelberg, Germany;

    Institute of Physiology and Pathophysiology, Medical Faculty, University of Heidelberg, D-69120 Heidelberg, Germany;

    Institute of Physiology and Pathophysiology, Medical Faculty, University of Heidelberg, D-69120 Heidelberg, Germany;

    Neurowissenschaftliches Forschungszentrum, Charite-Universitatsmedizin Berlin, Cluster of Excellence, NeuroCure, D-10117 Berlin, Germany;

    Neurowissenschaftliches Forschungszentrum, Charite-Universitatsmedizin Berlin, Cluster of Excellence, NeuroCure, D-10117 Berlin, Germany;

    Laboratory of Genetic Neuropharmacology, McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, MA 02478;

    Institute of Anatomy and Cell Biology, University of Freiburg, D-79104 Freiburg, Germany,Center for Molecular Neurobiology Hamburg, D-20251 Hamburg, Germany;

    BM T. J. Watson Research Center, Yorktown Heights, NY 10598;

    Institute of Physiology and Pathophysiology, Medical Faculty, University of Heidelberg, D-69120 Heidelberg, Germany;

    Institute of Physiology and Pathophysiology, Medical Faculty, University of Heidelberg, D-69120 Heidelberg, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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