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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Autopsy series of 68 cases dying before and during the 1918 influenza pandemic peak
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Autopsy series of 68 cases dying before and during the 1918 influenza pandemic peak

机译：在1918年流感大流行高峰之前和之中死亡的68例尸检系列

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摘要

The 1918 to 1919 "Spanish" influenza pandemic virus killed up to 50 million people. We report here clinical, pathological, bacteriological, and virological findings in 68 fatal American influenza/ pneumonia military patients dying between May and October of 1918, a period that includes ~4 mo before the 1918 pandemic was recognized, and 2 mo (September-October 1918) during which it appeared and peaked. The lung tissues of 37 of these cases were positive for influenza viral antigens or viral RNA, including four from the prepandemic period (May-August). The prepandemic and pandemic peak cases were indistinguishable clinically and pathologically. All 68 cases had histological evidence of bacterial pneumonia, and 94% showed abundant bacteria on Gram stain. Sequence analysis of the viral hemagglutinin receptor-binding domain performed on RNA from 13 cases suggested a trend from a more "avian-like" viral receptor specificity with G222 in prepandemic cases to a more "human-like" specificity associated with D222 in pandemic peak cases. Viral antigen distribution in the respiratory tree, however, was not apparently different between prepandemic and pandemic peak cases, or between infections with viruses bearing different receptor-binding polymorphisms. The 1918 pandemic virus was circulating for at least 4 mo in the United States before it was recognized epidemiologically in September 1918. The causes of the unusually high mortality in the 1918 pandemic were not explained by the pathological and virological parameters examined. These findings have important implications for understanding the origins and evolution of pandemic influenza viruses.
机译：1918年至1919年的“西班牙”流感大流行病毒杀死了多达5000万人。我们在此报告1918年5月至10月之间死亡的68例致命的美国流感/肺炎军人的临床，病理，细菌学和病毒学发现，这段时期包括1918年大流行之前的约4个月和2个月（9月至10月） 1918年）期间出现并达到顶峰。这些病例中有37例的肺组织中流感病毒抗原或病毒RNA呈阳性，包括大流行前期（5月至8月）的4例。大流行前和大流行高峰病例在临床和病理上是无法区分的。 68例均具有细菌性肺炎的组织学证据，其中94％革兰氏染色显示细菌丰富。从13例病例中对RNA进行的病毒血凝素受体结合结构域的序列分析表明，从大流行前病例中G222的“禽样”病毒受体特异性更高，到大流行病高峰中与D222相关的“人样”特异性都有趋势案件。然而，在大流行前和大流行高峰之间，或在感染具有不同受体结合多态性的病毒之间，呼吸树中的病毒抗原分布没有明显差异。 1918年大流行性病毒在美国流行至少4个月，然后在1918年9月被流行病学识别。在1918年大流行中异常高死亡率的原因尚未通过所检查的病理和病毒学参数来解释。这些发现对于理解大流行性流感病毒的起源和进化具有重要意义。

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    Zong-Mei Sheng; Daniel S. Chertow; Xavier Ambroggio; Sherman McCall; Ronald M. Przygodzki; Robert E. Cunningham; Olga A. Maximova; John C. Kash; David M. Morens; Jeffery K. Taubenberger;

  • 作者单位

    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, , National Institutes of Health, Bethesda, MD 20892;

    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, , National Institutes of Health, Bethesda, MD 20892;

    Bioinformatics and Computational Biosciences Branch, , National Institutes of Health, Bethesda, MD 20892;

    Clinical Pathology Laboratory, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702;

    Department of Veterans Affairs, Washington, DC 20420;

    Department of Biophysics, Armed Forces Institute of Pathology, Rockville, MD 20850;

    Office of the Chief, Laboratory of Infectious Diseases, , National Institutes of Health, Bethesda, MD 20892;

    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, , National Institutes of Health, Bethesda, MD 20892;

    Office of the Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;

    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, , National Institutes of Health, Bethesda, MD 20892;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    archaevirology; postmortem; immunohistochemistry;

    机译：考古病毒学验尸免疫组化;

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