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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Phage auxiliary metabolic genes and the redirection of cyanobacterial host carbon metabolism
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Phage auxiliary metabolic genes and the redirection of cyanobacterial host carbon metabolism

机译:噬菌体辅助代谢基因与蓝细菌宿主碳代谢的重定向

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摘要

Approximately half of all photosynthesis on Earth takes place in the ocean, and a sizable portion of that is carried out by tiny (about 1 μm in diameter) unicellular cyanobacteria, or blue-green algae, called Prochlorococcus and Synechococcus, which often reach densities of 100 million per liter of seawater. Even more abundant are viruses, called cyanophage, that can attach to these "host" cells, inject their DNA, and use the host's biochemical machinery to make more phage. The phage then break open the host cell, killing it, and release their progeny into the seawater. One of the ways cyanophages are thought to take over their hosts is via the use of host-like metabolic genes-acquired over eons of intimate coevolution-that encode enzymes that boost metabolic steps that might be bottlenecks in the phage reproduction process.
机译:地球上所有光合作用的大约一半发生在海洋中,其中相当大的一部分是由微小的(直径约1μm)单细胞蓝细菌或蓝藻(称为Prochlorococcus和Synechococcus)进行的。每升海水1亿。更加丰富的是被称为蓝藻的病毒,它们可以附着在这些“宿主”细胞上,注入其DNA,并利用宿主的生化机制制造更多的噬菌体。噬菌体然后打开宿主细胞,杀死它,并将其后代释放到海水中。蓝藻被认为可以接管其宿主的一种方式是通过使用宿主的代谢基因(它们是通过亲密共进化的基因获得的),该基因编码的酶可以促进可能是噬菌体繁殖过程瓶颈的代谢步骤。

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    Departments of Biology Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139;

    Departments of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139;

    Departments of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139;

    Departments of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139;

    Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario Canada M5G 1L6;

    Departments of Biology Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139,Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139;

    Departments of Biology Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139,Departments of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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