Timing molecular motion and production with a synthetic transcriptional clock

Elisa Franco; Eike Friedrichs; Jongmin Kim; Ralf Jungmann; Richard Murray; Erik Winfree; Friedrich C. Simmel

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Timing molecular motion and production with a synthetic transcriptional clock

机译：用合成转录时钟计时分子运动和产生

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Biological and computational systems need "timing" to operate properly. Digital clock generators synchronize the states of millions of transistors in silicon circuits, while circadian rhythms similarly orchestrate biological processes in complex organisms (1). Systematic methods for the design of clocked electronic circuits are available. However, the same is not true for biochemical circuits, which present challenges unique to the molecular context: for instance, it is not obvious whether a system can be subdivided into functional modules, and signals do not propagate through "wires." Here, we study such challenges through a model problem: we use a synthetic, cell-free biochemical oscillator to drive several different molecular "loads." In all cases the load causes a deterioration of the oscillator signal. We demonstrate that the perturbation can be efficiently reduced by placing a signal amplification device between the oscillator and the load process.

机译：生物和计算系统需要“定时”才能正常运行。数字时钟发生器可以同步硅电路中数百万个晶体管的状态，而昼夜节律也可以协调复杂生物中的生物过程（1）。提供了用于设计时钟电子电路的系统方法。但是，对于生化回路而言，情况却并非如此，生化回路提出了分子环境所特有的挑战：例如，将系统细分为功能模块以及信号不通过“导线”传播都并不明显。在这里，我们通过模型问题研究此类挑战：我们使用合成的无细胞生化振荡器来驱动几种不同的分子“负载”。在所有情况下，负载都会导致振荡器信号变差。我们证明了通过在振荡器和负载过程之间放置一个信号放大装置可以有效地减少干扰。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2011年第40期|p.16495-16496|共2页
作者
Elisa Franco; Eike Friedrichs; Jongmin Kim; Ralf Jungmann; Richard Murray; Erik Winfree; Friedrich C. Simmel;
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作者单位

Control and Dynamical Systems, California Institute of Technology, Pasadena, CA 91125;

Lehrstuhl fuer Bioelektronik, Physik Department, Technische Universitaet Munchen, Am Coulombwall 4a, 85748 Garching, Germany;

Bioengineering, California Institute of Technology, Pasadena, CA 91125;

Lehrstuhl fuer Bioelektronik, Physik Department, Technische Universitaet Munchen, Am Coulombwall 4a, 85748 Garching, Germany;

Control and Dynamical Systems, California Institute of Technology, Pasadena, CA 91125;

Bioengineering, California Institute of Technology, Pasadena, CA 91125,Computation and Neural Systems, California Institute of Technology, Pasadena, CA 91125,Computer Science, California Institute of Technology,Pasadena, CA 91125;

Lehrstuhl fuer Bioelektronik, Physik Department, Technische Universitaet Munchen, Am Coulombwall 4a, 85748 Garching, Germany;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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1. Circadian Clock genes Per2 and clock regulate steroid production, cell proliferation, and luteinizing hormone receptor transcription in ovarian granulosa cells. [J] . Shimizu T, Hirai Y, Murayama C, Biochemical and Biophysical Research Communications . 2011,第1期

机译：昼夜节律基因Per2和Clock调节卵巢颗粒细胞中的类固醇生成，细胞增殖和促黄体生成激素受体转录。
2. Circadian Clock genes Per2 and clock regulate steroid production, cell proliferation, and luteinizing hormone receptor transcription in ovarian granulosa cells. [J] . Shimizu T, Hirai Y, Murayama C, Biochemical and Biophysical Research Communications . 2011,第1期

机译：昼夜节律基因Per2和Clock调节卵巢颗粒细胞中的类固醇生成，细胞增殖和促黄体生成激素受体转录。
3. Determining Circadian Response of Adult Male Acrobasis nuxvorella (Lepidoptera: Pyralidae) to Synthetic Sex Attractant Pheromone Through Time-Segregated Trapping With a New Clockwork Timing Trap [J] . Stevenson Douglass E., Harris Marvin K. Environmental Entomology . 2009,第6期

机译：通过使用新的发条计时陷阱的时间分隔诱捕确定成年雄性杂技（鳞翅目：拟翅目）对合成的性吸引信息素的昼夜节律响应。
4. Building higher resolution synthetic clocks for signaling in covert timing channels [C] . Janeri, J.V.A., Darby, . 1995

机译：构建更高分辨率的合成时钟以在隐秘的定时通道中发信号
5. The skeletal muscle molecular clock regulates the timing of substrate metabolism and the circadian expression of Titin-cap [D] . Hodge, Brian A. 2015

机译：骨骼肌分子时钟调节底物新陈代谢的时间和Titin-cap的昼夜节律表达
6. PNAS Plus: Timing molecular motion and production with a synthetic transcriptional clock [O] . Elisa Franco, Eike Friedrichs, Jongmin Kim, 2011

机译：PNAS Plus：使用合成转录时钟计时分子运动和产生
7. Timing molecular motion and production with a synthetic transcriptional clock [O] . Franco Elisa, Friedrichs Eike, Kim Jongmin, 2011

机译：用合成转录时钟计时分子运动和产生
8. Ultracold Molecules in Optical Lattices: Efficient Production and Application to Molecular Clocks. [R] . Zelevinsky, T. 2015

机译：光学格子中的超冷分子：分子钟的高效生产和应用。

Timing molecular motion and production with a synthetic transcriptional clock

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