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QnAs with Robert C. Malenka

机译:Robert C. Malenka的QnA

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摘要

Experiences bridge brain circuitry with behavior, affecting our ability to learn and remember. By influ encing the nature of neurotrans mission across synapses-junctions between nerve cells-experiences can physically shape the mind. Those influen ces, collectively termed synaptic plasticity, have been a focus of study for neurosci entist Robert Malenka for more than two decades. Malenka, a member of the Na tional Academy of Sciences, has un covered molecular mechanisms underlying synaptic plasticity. Along the way, he has pinpointed changes in a raft of synaptic proteins that can alter the efficacy of neurotransmission across synapses. An offshoot of his studies on synaptic plas ticity, Malenka's work on how drugs such as cocaine and amphetamines can affect synapses in various brain regions has re vealed insights into the biological basis of drug addiction. Malenka offers a primer on synaptic plasticity for PNAS readers.
机译:体验将大脑回路与行为联系起来,影响我们的学习和记忆能力。通过影响跨突触的神经传递的本质-神经细胞之间的连接,体验可以在物理上塑造心灵。那些影响被统称为突触可塑性,已经成为神经科学专家罗伯特·马林卡(Robert Malenka)二十多年来的研究重点。美国国家科学院院士Malenka对突触可塑性具有潜在的分子机制。在此过程中,他指出了一系列突触蛋白的变化,这些变化可以改变跨突触的神经传递的功效。 Malenka在其关于突触可塑性的研究的一个分支中,研究可卡因和安非他明之类的药物如何影响大脑各个区域的突触,这揭示了对药物成瘾的生物学基础的见解。 Malenka为PNAS读者提供了突触可塑性的入门知识。

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