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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Frequency selectivity in Old-World monkeys corroborates sharp cochlear tuning in humans
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Frequency selectivity in Old-World monkeys corroborates sharp cochlear tuning in humans

机译：老式猴子的频率选择性证实了人类耳蜗的急剧调谐

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摘要

Frequency selectivity in the inner ear is fundamental to hearing and is traditionally thought to be similar across mammals. Although direct measurements are not possible in humans, estimates of frequency tuning based on noninvasive recordings of sound evoked from the cochlea (otoacoustic emissions) have suggested substantially sharper tuning in humans but remain controversial. We report measurements of frequency tuning in macaque monkeys, Old-World primates phylogenetically closer to humans than the laboratory animals often taken as models of human hearing (e.g., cats, guinea pigs, chinchillas). We find that measurements of tuning obtained directly from individual auditory-nerve fibers and indirectly using otoacoustic emissions both indicate that at characteristic frequencies above about 500 Hz, peripheral frequency selectivity in macaques is significantly sharper than in these common laboratory animals, matching that inferred for humans above 4-5 kHz. Compared with the macaque, the human otoacoustic estimates thus appear neither prohibitively sharp nor exceptional. Our results validate the use of otoacoustic emissions for noninvasive measurement of cochlear tuning and corroborate the finding of sharp tuning in humans. The results have important implications for understanding the mechanical and neural coding of sound in the human cochlea, and thus for developing strategies to compensate for the degradation of tuning in the hearing-impaired.
机译：内耳的频率选择性是听力的基础，传统上认为在哺乳动物之间是相似的。尽管无法在人体中进行直接测量，但基于从耳蜗诱发的声音的非侵入性录音（耳声发射）进行频率调谐的估计表明，在人体中调谐的频率明显更高，但仍存在争议。我们报告了猕猴的频率调谐的测量结果，它们比通常被用作人类听力模型的实验动物（例如猫，豚鼠，龙猫）在系统发育上更接近人类。我们发现，直接从单个听觉神经纤维和间接使用耳声发射获得的调谐测量结果都表明，在特征频率高于约500 Hz时，猕猴的外周频率选择性比这些普通实验动物明显更强，与人类推断的相匹配。高于4-5 kHz。因此，与猕猴相比，人类的耳声估计既不显得异常尖锐也不例外。我们的结果验证了耳声发射在耳蜗调谐非侵入性测量中的应用，并证实了人类急剧调谐的发现。这些结果对于理解人类耳蜗中声音的机械和神经编码，从而为补偿听力受损的听音调音的发展策略具有重要意义。

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