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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Temporally structured metapopulation dynamics and persistence of influenza A H3N2 virus in humans
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Temporally structured metapopulation dynamics and persistence of influenza A H3N2 virus in humans

机译：甲型H3N2流感病毒在人体内的暂时结构化种群动态和持久性

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摘要

Populations of seasonal influenza virus experience strong annual bottlenecks that pose a considerable extinction risk. It has been suggested that an influenza source population located in tropical Southeast or East Asia seeds annual temperate epidemics. Here we investigate the seasonal dynamics and migration patterns of influenza A H3N2 virus by analysis of virus samples obtained from 2003 to 2006 from Australia, Europe, Japan, New York, New Zealand, Southeast Asia, and newly sequenced viruses from Hong Kong. In contrast to annual temperate epidemics, relatively low levels of relative genetic diversity and no seasonal fluctuations characterized virus populations in tropical Southeast Asia and Hong Kong. Bayesian phylogeographic analysis using discrete temporal and spatial characters reveal high rates of viral migration between urban centers tested. Although the virus population that migrated between Southeast Asia and Hong Kong persisted through time, this was dependent on virus input from temperate regions and these tropical regions did not maintain a source for annual H3N2 influenza epidemics. We further show that multiple lineages may seed annual influenza epidemics, and that each region may function as a potential source population. We therefore propose that the global persistence of H3N2 influenza A virus is the result of a migrating metapopulation in which multiple different localities may seed seasonal epidemics in temperate regions in a given year. Such complex global migration dynamics may confound control efforts and contribute to the emergence and spread of antigenic variants and drug-resistant viruses.
机译：季节性流感病毒的种群每年都面临严重的瓶颈，这构成了相当大的灭绝风险。已经提出，位于热带东南亚或东亚的流感源人群每年都在温带流行。在这里，我们通过分析从澳大利亚，欧洲，日本，纽约，新西兰，东南亚从2003年至2006年获得的病毒样本以及从香港获得的新测序病毒，分析了甲型H3N2流感病毒的季节性动态和迁移方式。与每年的温带流行相反，热带东南亚和香港的病毒种群是相对较低的相对遗传多样性水平，没有季节性波动。使用离散的时空特征的贝叶斯系统地理分析表明，在测试的城市中心之间病毒迁移的速率很高。尽管在东南亚和香港之间迁移的病毒种群持续存在，但这取决于温带地区的病毒输入，而这些热带地区并没有保持每年H3N2流感流行的来源。我们进一步表明，多个谱系可能会播种每年的流感大流行，并且每个区域都可能充当潜在的来源人群。因此，我们提出，全球H3N2甲型流感病毒的持久性是迁移的人口迁移的结果，在该迁移人口中，多个不同的地区可能在给定年份在温带地区播种季节性流行病。这种复杂的全球迁移动态可能会混淆控制工作，并有助于抗原性变体和耐药性病毒的出现和传播。

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    Justin Bahl; Martha I. Nelson; Kwok H. Chan; Rubing Chen; Dhanasekaran Vijaykrishna; Rebecca A. Halpin; Timothy B. Stockwell; Xudong Lin; David E. Wentworth; Elodie Ghedin; Yi Guan; J. S. Malik Peiris; Steven Riley; Andrew Rambaut; Edward C. Holmes; Gavin J. D. Smith;

  • 作者单位

    Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Pokfulam, Hong Kong Special Admnistrative Region, China,Laboratory of Virus Evolution, Program in Emerging Infectious Diseases, Duke-National University of Singapore Graduate Medical School,Republic of Singapore 169857;

    Fogarty International Center, National Institutes of Health, Bethesda, MD 20892;

    Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Pokfulam, Hong Kong Special Admnistrative Region, China;

    University of Texas Medical Branch,Galveston, TX 77555;

    Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Pokfulam, Hong Kong Special Admnistrative Region, China,Laboratory of Virus Evolution, Program in Emerging Infectious Diseases, Duke-National University of Singapore Graduate Medical School,Republic of Singapore 169857;

    J. Craig Venter Institute, Rockville, MD 20850;

    J. Craig Venter Institute, Rockville, MD 20850;

    J. Craig Venter Institute, Rockville, MD 20850;

    J. Craig Venter Institute, Rockville, MD 20850;

    J. Craig Venter Institute, Rockville, MD 20850,Center for Vaccine Research, Department of Computational and Systems Biology,University of Pittsburgh School of Medicine, Pittsburgh, PA 15261;

    Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Pokfulam, Hong Kong Special Admnistrative Region, China;

    Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Pokfulam, Hong Kong Special Admnistrative Region, China,Hong Kong University-Pasteur Research Centre, University of Hong Kong, Pokfulam, Hong Kong Special Admnistrative Region, China;

    Department of Community Medicine and School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong Special Admnistrative Region, China,Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College, London W2 1PG, United Kingdom;

    Fogarty International Center, National Institutes of Health, Bethesda, MD 20892,Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom;

    Fogarty International Center, National Institutes of Health, Bethesda, MD 20892,Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, PA 16802;

    Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Pokfulam, Hong Kong Special Admnistrative Region, China,Laboratory of Virus Evolution, Program in Emerging Infectious Diseases, Duke-National University of Singapore Graduate Medical School,Republic of Singapore 169857;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    evolution; molecular epidemiology; source-sink; phylogeography;

    机译：演化;分子流行病学源库系谱学;

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