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FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders

机译:FGF2基因转移在阿尔茨海默氏病小鼠模型中恢复海马功能并对神经认知障碍具有治疗意义

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摘要

The adult hippocampus is a brain region that plays a central role in memory formation, syn-aptic plasticity (i.e., the ability of a neuron to change the strength of its response to stimulation from other neurons), and neu-rogenesis in the subgranular zone (SGZ), the process by which neurons are generated from cells that can differentiate into specific types of cells called progenitor cells. Reduced hippocampal neurogenesis is strongly associated with memory dysfunction in humans with age-associated cognitive dysfunction, further substantiating the emerging role of neurogenesis in hippocampal functions in the aged brain. In the Alzheimer's disease (AD) brain, hippocampal neurogenesis shows proliferation of neuronal progenitor cells in response to the disease but impairment in their maturation.
机译:成年海马是一个大脑区域,在记忆形成,突触可塑性(即神经元改变其对其他神经元刺激的反应强度的能力)以及颗粒下亚区的神经发生中起关键作用(SGZ),从细胞生成神经元的过程,可以分化为特定类型的细胞,称为祖细胞。在年龄相关的认知功能障碍的人中,海马神经发生的减少与记忆功能障碍密切相关,进一步证实了神经发生在老年大脑海马功能中的新兴作用。在阿尔茨海默氏病(AD)的大脑中,海马神经发生反应显示神经元祖细胞增殖,但其成熟受到损害。

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    Departments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198;

    Laboratory of Molecular NeuroTherapeutics, Departments of Pharmacology and Experimental Therapeutics and Neurology, and Alzheimer's Disease Center, Boston University School of Medicine, Boston, MA 02118;

    Departments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198;

    Departments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198;

    Departments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198,Laboratory of Molecular NeuroTherapeutics, Departments of Pharmacology and Experimental Therapeutics and Neurology, and Alzheimer's Disease Center, Boston University School of Medicine, Boston, MA 02118;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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