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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways
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Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways

机译：同源蛋白Phox2b命令在颅内感觉途径中进行体细胞到内脏的转换

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摘要

Taste and most sensory inputs required for the feedback regulation of digestive, respiratory, and cardiovascular organs are conveyed to the central nervous system by so-called "visceral" sensory neurons located in three cranial ganglia (geniculate, pe-trosal, and nodose) and integrated in the hindbrain by relay sensory neurons located in the nucleus of the solitary tract. Visceral sensory ganglia and the nucleus of the solitary tract all depend for their formation on the pan-visceral homeodomain transcription factor Phox2b, also required in efferent neurons to the viscera. We show here, by genetically tracing Phox2b~+ cells, that in the absence of the protein, many visceral sensory neurons (first- and second-order) survive. However, they adopt a fate-including molecular signature, cell positions, and axonal projections-akin to that of somatic sensory neurons (first- and second-order), located in the trigeminal, superior, and jugular ganglia and the trigeminal sensory nuclei, that convey touch and pain sensation from the oro-facial region. Thus, the cranial sensory pathways, somatic and visceral, are related, and Phox2b serves as a developmental switch from the former to the latter.
机译：消化，呼吸和心血管器官的反馈调节所需的味道和大多数感觉输入通过位于三个颅神经节（膝状，球状和结节状）的所谓“内脏”感觉神经元传递到中枢神经系统，通过位于孤立道核中的中继感觉神经元整合在后脑中。内脏感觉神经节和孤立道的核都取决于它们的形成取决于泛内脏同源域转录因子Phox2b，这也是内脏传出神经元所必需的。通过遗传追踪Phox2b〜+细胞，我们在这里表明，在缺乏蛋白质的情况下，许多内脏感觉神经元（一阶和二阶）得以存活。但是，它们的命运（包括分子标记，细胞位置和轴突投影）与位于三叉神经，上，颈静脉神经节和三叉神经感觉核中的体感神经元（一阶和二阶）的命运类似，传达了来自口腔面部区域的触觉和疼痛感。因此，颅的感觉途径，体细胞的和内脏的，是相关的，并且Phox2b充当了从前者到后者的发育转换。

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  • 作者

    Fabien DAutreaux; Eva Coppola; Marie-Rose Hirsch; Carmen Birchmeier; Jean-Francois Brunet;

  • 作者单位

    lnstitut de Biologie de I'Ecole Normale Superieure 75005 Paris, France,Centre National de la Recherche Scientifique, Unite Mixte de Recherche 8197, 75005 Paris, France,Institut National de la Sante et de la Recherche Medicale U1024, 75005 Paris, France;

    lnstitut de Biologie de I'Ecole Normale Superieure 75005 Paris, France,Centre National de la Recherche Scientifique, Unite Mixte de Recherche 8197, 75005 Paris, France,Institut National de la Sante et de la Recherche Medicale U1024, 75005 Paris, France;

    lnstitut de Biologie de I'Ecole Normale Superieure 75005 Paris, France,Centre National de la Recherche Scientifique, Unite Mixte de Recherche 8197, 75005 Paris, France,Institut National de la Sante et de la Recherche Medicale U1024, 75005 Paris, France;

    Department of Neuroscience, Max-Delbruck-Centrum for Molecular Medicine, D-13125 Berlin-Buch, Germany;

    lnstitut de Biologie de I'Ecole Normale Superieure 75005 Paris, France,Centre National de la Recherche Scientifique, Unite Mixte de Recherche 8197, 75005 Paris, France,Institut National de la Sante et de la Recherche Medicale U1024, 75005 Paris, France;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    neurona; differentiation; Brn3a/Pou4f1;

    机译：神经元分化Brn3a / Pou4f1;

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