...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Neurotrophin-mediated degradation of histone methyltransferase by S-nitrosylation cascade regulates neuronal differentiation
【24h】

Neurotrophin-mediated degradation of histone methyltransferase by S-nitrosylation cascade regulates neuronal differentiation

机译：神经营养蛋白介导的S-亚硝基化级联降解组蛋白甲基转移酶调节神经元分化

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Epigenetic regulation of histones mediates neurotrophin actions with histone acetylation enhancing cAMP response element-binding (CREB)-associated transcription elicited by brain-derived neurotrophic factor (BDNF) and nerve-growth factor (NGF). Roles for histone methylation in CREB's transcriptional activity have not been well characterized. We show that depletion of the histone methyltransferase suppressor of variegation 3-9 homolog 1 (SUV39H1) selectively augments BDNF- and NGF-mediatefl neurite outgrowth. SUV39H1 is the principal enzyme responsible for tri-methylation of histone H3 at lysine 9, a molecular mark associated with transcriptional silencing. BDNF and NGF act via a signaling cascade wherein degradation of SUV39H1 down-regulates trimethylation of H3K9 in a nitric oxide-dependent pathway. BDNF activates neuronal NOS with the nitrosylated GAPDH/seven in absentia (Siah) homolog complex translocating to the nucleus. Degradation of SUV39H1 by Siah facilitates histone H3 on lysine 9 acetylation, CREB binding to DNA, enhanced expression of CREB-regulated genes and neurite outgrowth.
机译：组蛋白的表观遗传调控通过组蛋白乙酰化增强神经营养因子的作用，组蛋白乙酰化增强了脑源性神经营养因子（BDNF）和神经生长因子（NGF）引起的cAMP反应元件结合（CREB）相关转录。组蛋白甲基化在CREB转录活性中的作用尚未很好地表征。我们显示，变体3-9同源1（SUV39H1）的组蛋白甲基转移酶抑制剂的耗竭选择性地增加BDNF-和NGF-mediatefl神经突增生。 SUV39H1是负责组氨酸H3在赖氨酸9（与转录沉默相关的分子标记）上的三甲基化的主要酶。 BDNF和NGF通过信号转导级联起作用，其中SUV39H1的降解以一氧化氮依赖性途径下调H3K9的三甲基化。 BDNF用亚硝基化的GAPDH /缺席症（Siah）同源复合物中的七位转移到细胞核来激活神经元NOS。 Siah对SUV39H1的降解促进了组蛋白H3赖氨酸9的乙酰化，CREB与DNA的结合，CREB调控基因的表达增强和神经突增生。

著录项

  • 来源
  • 作者

    Nilkantha Sen; Solomon H. Snyder;

  • 作者单位

    The Solomon H. Snyder Department of Neuroscience and Departments;

    The Solomon H. Snyder Department of Neuroscience and Departments,Pharmacology and Molecular Sciences,Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    epigenetics; GAPDH;

    机译：表观遗传学GAPDH;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号