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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The electrochemistry of quinizarin revealed through its mediated reduction of oxygen
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The electrochemistry of quinizarin revealed through its mediated reduction of oxygen

机译：奎尼沙林的电化学通过其介导的氧还原而揭示

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摘要

After 35 years the hunt for improved anthracycline antibiotics is unabated but has yet to achieve the levels of clinical success desired. Electrochemical techniques provide a large amount of kinetic and thermodynamic information, but the use of such procedures is hindered by issues of sensitivity and selectivity. This work demonstrates how by harnessing the mechanism of catalytic reduction of oxygen by the quinone functionality present within the anthracycline structure it is possible to study the reactive moiety in nanomolar concentration. This methodology allows electrochemical investigation of the intercalation of quinizarin into DNA and, in particular, the quinone oxidation and degradation mechanism. The reversible reduction of the quinizarin, which in the presence of oxygen leads to the formation of reactive oxygen species, is found to occur at -0.535 V (vs. SCE) pH 6.84 and the irreversible oxidation leading to the molecules degradation occurs at +0.386 V (vs. SCE) pH 6.84.
机译：35年后，寻找改良的蒽环类抗生素的努力并未减弱，但尚未达到所需的临床成功水平。电化学技术提供了大量的动力学和热力学信息，但是由于灵敏度和选择性问题，此类程序的使用受到了阻碍。这项工作证明了如何利用蒽环类化合物结构内存在的醌官能团来催化氧的还原反应机理，从而有可能研究纳摩尔浓度的反应性部分。这种方法可以电化学研究奎尼沙林插入DNA中的过程，尤其是醌氧化和降解机理。奎尼西林的可逆还原发生在氧气存在下导致形成活性氧，在-0.535 V（vs. SCE）pH 6.84下发生，并且导致分子降解的不可逆氧化发生在+0.386上V（vs.SCE）pH 6.84。

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  • 作者

    Christopher Batchelor-McAuley; Ivan B. Dimov; Leigh Aldous; Richard G. Compton;

  • 作者单位

    Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, Oxford 0X1 3QZ, United Kingdom;

    Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, Oxford 0X1 3QZ, United Kingdom;

    Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, Oxford 0X1 3QZ, United Kingdom;

    Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, Oxford 0X1 3QZ, United Kingdom;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    electrocatalysis; oxygen reduction; boron-doped diamond;

    机译：电催化氧气还原掺硼金刚石;

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