Human milk glycobiome and its impact on the infant gastrointestinal microbiota

Angela M. Zivkovic; J. Bruce German; Carlito B. LebriMa; David A. Mills

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Human milk glycobiome and its impact on the infant gastrointestinal microbiota

机译：人乳糖组学及其对婴儿胃肠道菌群的影响

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Human milk contains an unexpected abundance and diversity of complex oligosaccharides apparently indigestible by the developing infant and instead targeted to its cognate gastrointestinal micro-biota. Recent advances in mass spectrometry-based tools have provided a view of the oligosaccharide structures produced in milk across stages of lactation and among human mothers. One postulated function for these oligosaccharides is to enrich a specific "healthy" microbiota containing bifidobacteria, a genus commonly observed in the feces of breast-fed infants. Isolated culture studies indeed show selective growth of infant-borne bifidobacteria on milk oligosaccharides or core components therein. Parallel glycoprofiling documented that numerous Bifidobacterium longum subsp. infantis strains preferentially consume small mass oligosaccharides that are abundant early in the lactation cycle. Genome sequencing of numerous B. longum subsp. infantis strains shows a bias toward genes required to use mammalian-derived carbohydrates by comparison with adult-borne bifidobacteria. This intriguing strategy of mammalian lactation to selectively nourish genetically compatible bacteria in infants with a complex array of free oligosaccharides serves as a model of how to influence the human supraorganismal system, which includes the gastrointestinal microbiota.

机译：人乳中含有意想不到的丰富和复杂的低聚糖，这些糖显然不适合发育中的婴儿消化，而是针对其相关的胃肠道微生物群。基于质谱的工具的最新进展提供了在哺乳阶段和人类母亲之间牛奶中产生的寡糖结构的观点。这些低聚糖的一种假定功能是丰富特定的“健康”微生物群，其中含有双歧杆菌，这是在母乳喂养婴儿的粪便中常见的一种。分离培养研究确实显示了婴儿传播的双歧杆菌在牛奶寡糖或其中的核心成分上的选择性生长。平行糖谱分析表明，许多长双歧杆菌亚种。婴儿菌株优先消耗在泌乳周期早期丰富的小质量低聚糖。许多长双歧杆菌亚种的基因组测序。与成人传播的双歧杆菌相比，婴儿菌株对使用哺乳动物衍生的碳水化合物所需的基因表现出偏见。哺乳动物泌乳的一种有趣策略是通过复杂的一系列游离寡糖选择性地喂养婴儿中的遗传相容细菌，以此作为影响包括胃肠道微生物群在内的人类超生物体系统的模型。

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2011年第11suppla期|p.4653-4658|共6页
作者
Angela M. Zivkovic; J. Bruce German; Carlito B. LebriMa; David A. Mills;
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作者单位

Foods for Health Institute,Department of Food Science and Technology,Functional Glycobiology Program;

Foods for Health Institute,Department of Food Science and Technology,Functional Glycobiology Program;

Foods for Health Institute,Functional Glycobiology Program,Department of Chemistry,Department of Biochemistry and Molecular Medicine;

Foods for Health Institute,Functional Glycobiology Program,Robert Mondavi Institute for Wine and Food Science,Department of Viticulture and Enology, University of California, Davis, CA 95616;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类
关键词
glycoprofiling; human milk oligosaccharides; infant microbiota; bifidobacterium; diet;

机译：糖谱分析;人乳寡糖;婴儿微生物群;双歧杆菌;饮食;

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1. In vitro comparative evaluation of the impact of lacto-N-biose I, a major building block of human milk oligosaccharides, on the fecal microbiota of infants [J] . Takumi Satoh, Toshitaka Odamaki, Mariko Namura, Anaerobe . 2013,第2期

机译：乳酸-N-二糖I（人乳寡糖的主要组成部分）对婴儿粪便微生物群的影响的体外比较评估
2. In vitro comparative evaluation of the impact of lacto-N-biose I, a major building block of human milk oligosaccharides, on the fecal microbiota of infants [J] . Takumi Satoh, Toshitaka Odamaki, Mariko Namura, Anaerobe . 2013,第Null期

机译：乳酸-N-二糖I（人乳寡糖的主要组成部分）对婴儿粪便微生物群的影响的体外比较评估
3. In vitro comparative evaluation of the impact of lacto-N-biose I, a major building block of human milk oligosaccharides, on the fecal microbiota of infants [J] . Takumi Satoh, Toshitaka Odamaki, Mariko Namura, Anaerobe . 2013,第Null期

机译：体外比较评价Lacto-n-Biose i，婴儿粪便微生物的主要建筑物块
4. Exploration and Comparison of Milk Whey Proteins from Human Milk, Cow's Milk and Infant Formula Using Non-Gel-based Proteomics Approach [C] . Qiang Zhang, Anh Le, Jeff Sanders American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

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5. The detection and epidemiology of parasitic gastrointestinal nematode infection in Zanzibari infants: The association between infection status of nursing infants and cytokines present in human milk. [D] . Goodman, David Alan. 2006

机译：Zanzibari婴儿的寄生虫胃肠线虫感染的检测和流行病学：护理婴儿的感染状况与母乳中细胞因子之间的关联。
6. Colloquium Paper: Human milk glycobiome and its impact on the infant gastrointestinal microbiota [O] . Angela M. Zivkovic, J. Bruce German, Carlito B. Lebrilla, 2011

机译：讨论会论文：人乳糖组学及其对婴儿胃肠道菌群的影响
7. Human milk glycobiome and its impact on the infant gastrointestinal microbiota [O] . A. M. Zivkovic, J. B. German, C. B. Lebrilla, 2010

机译：人乳糖胆甙及其对婴儿胃肠道微生物的影响

Human milk glycobiome and its impact on the infant gastrointestinal microbiota

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