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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Epithelial crosstalk at the microbiota-mucosal interface
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Epithelial crosstalk at the microbiota-mucosal interface

机译：微生物群-粘膜界面的上皮串扰

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摘要

This article provides an overview of how intestinal epithelial cells (IEC) recognize commensals and how they maintain host-bacterial symbiosis. Endocrine, goblet cells, and enterocytes of the intestinal epithelium express a range of pattern recognition receptors (PRR) to sense the presence of microbes. The best characterized are the Toll-like receptors (TLR) and nucleotide oligomerization domain-like receptors (NLR), which play a key role in pathogen recognition and the induction of innate effectors and inflammation. Several adaptations of PRR signaling have evolved in the gut to avoid uncontrolled and potentially destructive inflammatory responses toward the resident microbiota. PRR signaling in IEC serve to maintain the barrier functions of the epithelium, including the production of secretory IgA (slgA). Additionally, lECs play a cardinal role in setting the immunosuppressive tone of the mucosa to inhibit overreaction against innocuous luminal antigens. This includes regulation of dendritic cells (DC), macrophage and lymphocyte functions by epithelial secreted cytokines. These immune mechanisms depend heavily on IEC recognition of microbes and are consistent with several studies in knockout mice that demonstrate TLR signaling in the epithelium has a profoundly beneficial role in maintaining homeostasis.
机译：本文概述了肠道上皮细胞（IEC）如何识别共生菌，以及它们如何维持宿主细菌共生。肠上皮的内分泌，杯状细胞和肠上皮细胞表达一系列模式识别受体（PRR），以检测微生物的存在。最具特征的是Toll样受体（TLR）和核苷酸寡聚化域样受体（NLR），它们在病原体识别以及先天效应子和炎症的诱导中起关键作用。 PRR信号转导的几种适应方式已在肠​​道中发展，以避免对驻留微生物的失控和潜在破坏性炎症反应。 IEC中的PRR信号用于维持上皮的屏障功能，包括分泌性IgA（slgA）的产生。另外，lEC在设定粘膜的免疫抑制基调以抑制对无毒管腔抗原的过度反应中起主要作用。这包括通过上皮分泌的细胞因子对树突状细胞（DC），巨噬细胞和淋巴细胞功能的调节。这些免疫机制在很大程度上取决于IEC对微生物的识别，并且与基因敲除小鼠中的多项研究一致，这些研究表明上皮中的TLR信号传导在维持体内平衡方面具有非常有益的作用。

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  • 作者

    Jerry M. Wells; Oriana Rossi; Marjolein Meijerink; Peter van Baarlen;

  • 作者单位

    Host-Microbe Interactomics Group, Animal Sciences, Wageningen University, 6700 AH Wageningen, The Netherlands,Top Institute Food and Nutrition,6709 PA, Wageningen, The Netherlands;

    Host-Microbe Interactomics Group, Animal Sciences, Wageningen University, 6700 AH Wageningen, The Netherlands;

    Host-Microbe Interactomics Group, Animal Sciences, Wageningen University, 6700 AH Wageningen, The Netherlands,Top Institute Food and Nutrition,6709 PA, Wageningen, The Netherlands;

    Host-Microbe Interactomics Group, Animal Sciences, Wageningen University, 6700 AH Wageningen, The Netherlands,Top Institute Food and Nutrition,6709 PA, Wageningen, The Netherlands;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    homeostasis; immunity; intestinal epithelium; toll-like receptors;

    机译：体内稳态;免疫;肠上皮;toll样受体;

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