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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Sex difference in the near-24-hour intrinsic period of the human circadian timing system
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Sex difference in the near-24-hour intrinsic period of the human circadian timing system

机译：人类昼夜节律计时系统近24小时内在周期中的性别差异

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摘要

The circadian rhythms of melatonin and body temperature are set to an earlier hour in women than in men, even when the women and men maintain nearly identical and consistent bedtimes and wake times. Moreover, women tend to wake up earlier than men and exhibit a greater preference for morning activities than men. Although the neurobiological mechanism underlying this sex difference in circadian alignment is unknown, multiple studies in nonhuman animals have demonstrated a sex difference in circadian period that could account for such a difference in circadian alignment between women and men. Whether a sex difference in intrinsic circadian period in humans underlies the difference in circadian alignment between men and women is unknown. We analyzed precise estimates of, intrinsic circadian period collected from 157 individuals (52 women, 105 men; aged 18-74 y) studied in a month-long inpatient protocol designed to minimize confounding influences on circadian period estimation. Overall, the average intrinsic period of the melatonin and temperature rhythms in this population was very close to 24 h [24.15 ± 0.2 h (24 h 9 min ±12 min)]. We further found that the intrinsic circadian period was significantly shorter in women [24.09 ± 0.2 h (24 h 5 min ± 12 min)] than in men [24.19 + 0.2 h (24 h 11 min ± 12 min); P < 0.01] and that a significantly greater proportion of women have intrinsic circadian periods shorter than 24.0 h (35% vs. 14%; P < 0.01). The shorter average intrinsic circadian period observed in women may have implications for understanding sex differences in habitual sleep duration and insomnia prevalence.
机译：女性的褪黑激素昼夜节律和体温设定为比男性早，即使女性和男性保持几乎相同且一致的就寝时间和起床时间。此外，女性往往比男性更早起床，并且比男性更喜欢参加早晨活动。尽管尚不清楚昼夜节律的性别差异的神经生物学机制，但对非人类动物的多项研究表明，昼夜节律的性别差异可能解释了男女昼夜节律差异的原因。尚不清楚人类内在昼夜节律时期的性别差异是否是男女昼夜节律一致性差异的基础。我们分析了在一个月的住院方案中研究的，从157个个体（52名女性，105名男性；年龄在18-74岁）中收集的内在昼夜节律周期的精确估计，该协议旨在最大程度地减少对昼夜节律周期估计的影响。总体而言，该人群中褪黑激素的平均固有周期和温度节律非常接近24小时[24.15±0.2小时（24小时9分钟±12分钟）]。我们进一步发现女性的内在昼夜节律周期[24.09±0.2 h（24 h 5 min±12 min）]明显短于男性[24.19 + 0.2 h（24 h 11 min±12 min）]。 P <0.01]，并且显着更大比例的女性的内在昼夜节律时间短于24.0 h（35％比14％； P <0.01）。在女性中观察到的较短的平均固有昼夜节律周期可能对理解习惯性睡眠持续时间和失眠患病率的性别差异有影响。

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    Jeanne F. Duffy; Sean W. Cain; Anne-Marie Chang; Andrew J. K. Phillips; Mirjam Y. Miinch; Claude Gronfier; James K. Wyatt; Derk-Jan Dijk; Kenneth P. Wright; Charles A. Czeisler;

  • 作者单位

    Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital and Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115;

    Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital and Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115;

    Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital and Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115;

    Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital and Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115;

    Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital and Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115;

    Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital and Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115;

    Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital and Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115;

    Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital and Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115;

    Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital and Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115;

    Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital and Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    biological rhythm; gender; phase angle;

    机译：生理节律;性别;相位角;

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