Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD

著录项

• 来源
  《Proceedings of the National Academy of Sciences of the United States of America》 |2010年第1期|413-418|共6页
• 作者

  Thor S. Thorsen; Kenneth L. Madsen; Nelson Rebola; Mette Rathje; Victor Anggono; Anders Bach; Irina S. Moreira; Nicolai Stuhr-Hansen; Tino Dyhring; Dan Peters; Thijs Beuming; Richard Huganir; Harel Weinstein; Christophe Mulle; Kristian Stromgaard; Lars Christian B. Ronn; Ulrik Gether;

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• 作者单位

  Molecular Neuropharmacology Group and Center for Pharmacogenomics, Department of Neuroscience and Pharmacology, The Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark;

  Molecular Neuropharmacology Group and Center for Pharmacogenomics, Department of Neuroscience and Pharmacology, The Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark;

  Laboratoire Physiologie Cellulaire de la Synapse, CNRS UMR 5091, Bordeaux Neuroscience Institute, University of Bordeaux, 33077 Bordeaux, France;

  Molecular Neuropharmacology Group and Center for Pharmacogenomics, Department of Neuroscience and Pharmacology, The Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark;

  Department of Neuroscience, The Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;

  Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark;

  Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY 10021;

  Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark;

  Drug Discovery, Neurosearch A/S, DK-2750 Ballerup, Denmark;

  Drug Discovery, Neurosearch A/S, DK-2750 Ballerup, Denmark;

  Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY 10021;

  Department of Neuroscience, The Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;

  Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY 10021;

  Laboratoire Physiologie Cellulaire de la Synapse, CNRS UMR 5091, Bordeaux Neuroscience Institute, University of Bordeaux, 33077 Bordeaux, France;

  Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark;

  Drug Discovery, Neurosearch A/S, DK-2750 Ballerup, Denmark;

  Molecular Neuropharmacology Group and Center for Pharmacogenomics, Department of Neuroscience and Pharmacology, The Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark;

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• 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
• 原文格式 PDF
• 正文语种 eng
• 中图分类
• 关键词

  drug discovery; fluorescence polarization; protein-protein interactions; synaptic plasticity; AMPA receptors;

  机译：药物发现;荧光偏振蛋白质相互作用突触可塑性AMPA受体;