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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Recognition memory signals in the macaque hippocampus
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Recognition memory signals in the macaque hippocampus

机译：猕猴海马体中的识别记忆信号

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摘要

The hippocampus plays a critical role in recognition memory in both monkeys and humans. However, neurophysiological studies have rarely reported recognition memory signals among hippocampal neurons. The majority of these previous studies used variants of the delayed match-to-sample task; however, studies of the effects of hippocampal damage in monkey and humans have shown that another task of recognition memory, the visual paired-comparison, or visual preferential looking task (VPLT), is more sensitive to hippocampal damage than the delayed matching tasks. Accordingly, to examine possible recognition memory signals in the hippocampus, we recorded the activity of 131 hippocampal neurons in two monkeys performing the VPLT. Eighty-eight neurons (67%) responded significantly to stimulus presentation relative to the baseline prestimulus period. A substantial proportion of these visually responsive neurons (36%) showed significant firing-rate modulations that reflected whether stimuli were novel or familiar. Additionally, these firing-rate modulations were correlated with recognition memory performance on the VPLT such that larger modulations by stimulus novelty were associated with better performance. Together, these results provide evidence for a neural signal in the hippocampus that may support recognition memory performance.
机译：海马在猴子和人类的识别记忆中都起着至关重要的作用。然而，神经生理学研究很少报道海马神经元之间的识别记忆信号。这些先前的研究大多数使用延迟的匹配样本任务的变体。然而，对猴子和人类海马损伤影响的研究表明，识别记忆的另一个任务，即视觉配对比较或视觉优先寻找任务（VPLT），比延迟匹配任务对海马损伤更敏感。因此，为了检查海马中可能的识别记忆信号，我们记录了两只进行VPLT的猴子中131个海马神经元的活动。相对于基线刺激前期，八十八个神经元（67％）对刺激表现有显着反应。这些视觉反应神经元中有很大一部分（36％）显示出明显的激发速率调节，反映出刺激是新颖的还是熟悉的。此外，这些激发速率调制与VPLT上的识别记忆性能相关，因此刺激性新颖的较大调制与更好的性能相关。总之，这些结果为海马中的神经信号提供了证据，该信号可能支持识别记忆功能。

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