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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >c-AbI tyrosine kinase regulates cardiac growth and development
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c-AbI tyrosine kinase regulates cardiac growth and development

机译：c-AbI酪氨酸激酶调节心脏的生长和发育

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摘要

The c-AbI protein is a ubiquitously expressed nonreceptor tyrosine kinase involved in the development and function of many mammalian organ systems, including the immune system and bone. Here we show that homozygous AbI mutant embryos and new-borns on the C57BL/6J background, but not on other backgrounds, display dramatically enlarged hearts and die perinatally. The heart defects can be largely rescued by cardiomyocyte-specific restoration of the full-length c-AbI protein. The cardiac hyperplasia phe-notype is not caused by decreased apoptosis, but rather by abnormally increased cardiomyocyte proliferation during later stages of embryogenesis. Genes involved in cardiac stress and remodeling and cell cycle regulation are also up-regulated in the mutant hearts. These findings reveal an essential role for c-AbI in mammalian heart growth and development.
机译：c-AbI蛋白是一种普遍表达的非受体酪氨酸激酶，参与许多哺乳动物器官系统（包括免疫系统和骨骼）的发育和功能。在这里，我们显示C57BL / 6J背景上的纯合AbI突变体胚胎和新生婴儿，但在其他背景上却没有，它们显示出心脏急剧扩大并在围产期死亡。通过全长c-AbI蛋白的心肌细胞特异性恢复，可以很大程度上挽救心脏缺陷。心脏增生的表型不是由凋亡减少引起的，而是由胚胎发生后期阶段异常增加的心肌细胞增殖引起的。在突变心脏中，与心脏应激，重塑和细胞周期调控有关的基因也被上调。这些发现揭示了c-AbI在哺乳动物心脏生长和发育中的重要作用。

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  • 作者

    Zhaozhu Qiu; Yong Cang; Stephen P. Goff;

  • 作者单位

    Departments of Microbiology, Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032;

    Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032 Burnham Institute for Medical Research, La Jolla, CA 92037;

    Departments of Microbiology, Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032 Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Abelson; heart development; hyperproliferation;

    机译：阿伯森心脏发育;过度增殖;

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