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Genetic control over the resting brain

机译：静息大脑的遗传控制

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摘要

The default-mode network, a coherent resting-state brain network, is thought to characterize basal neural activity. Aberrant default-mode connectivity has been reported in a host of neurological and psychiatric illnesses and in persons at genetic risk for such illnesses. Whereas the neurophysiologic mechanisms that regulate default-mode connectivity are unclear, there is growing evidence that genetic factors play a role. In this report, we estimate the importance of genetic effects on the default-mode network by examining covariation patterns in functional connectivity among 333 individuals from 29 randomly selected extended pedigrees. Heritability for default-mode functional connectivity was 0.424 ± 0.17 (P = 0.0046). Although neuroanatomic variation in this network was also heritable, the genetic factors that influence default-mode functional connectivity and gray-matter density seem to be distinct, suggesting that unique genes influence the structure and function of the network. In contrast, significant genetic correlations between regions within the network provide evidence that the same genetic factors contribute to variation in functional connectivity throughout the default mode. Specifically, the left parahippocampal region was genetically correlated with all other network regions. In addition, the posterior cingulate/precuneus region, medial prefrontal cortex, and right cerebellum seem to form a subnetwork. Default-mode functional connectivity is influenced by genetic factors that cannot be attributed to anatomic variation or a single region within the network. By establishing the heritability of default-mode functional connectivity, this experiment provides the obligatory evidence required before these measures can be considered as endopheno-types for psychiatric or neurological illnesses or to identify genes influencing intrinsic brain function.
机译：默认模式网络是一个相干的静止状态大脑网络，被认为可以表征基础神经活动。据报道，在许多神经系统疾病和精神疾病以及具有此类疾病遗传风险的人群中，都有默认的默认模式连接。尽管尚不清楚调节默认模式连接性的神经生理机制，但越来越多的证据表明遗传因素起作用。在本报告中，我们通过检查29个随机选择的扩展谱系中的333个个体之间的功能连通性协变模式，来估计遗传对默认模式网络的重要性。默认模式功能连接的遗传力为0.424±0.17（P = 0.0046）。尽管该网络中的神经解剖学变异也是可遗传的，但影响默认模式功能连接性和灰质密度的遗传因素似乎很明显，这表明独特的基因会影响网络的结构和功能。相反，网络内各区域之间的显着遗传相关性提供了证据，表明在整个默认模式下，相同的遗传因素会导致功能连接性发生变化。具体而言，左海马旁区域与所有其他网络区域遗传相关。此外，后扣带/前突区域，内侧前额叶皮层和右小脑似乎形成了一个亚网络。默认模式的功能连接受到遗传因素的影响，这些遗传因素不能归因于解剖结构变化或网络内的单个区域。通过建立默认模式功能连通性的遗传力，该实验提供了必需的强制性证据，然后这些措施才能被视为精神疾病或神经疾病的内表型，或识别影响内在大脑功能的基因。

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  • 作者

    D. C. Glahn; A. M. Winkler; P. Kochunov; L. Almasy; R. Duggirala; M. A. Carless; J. C. Curran; R. L. Olvera; A. R. Laird; S. M. Smith; C. F. Beckmann; P. T. Fox; J. Blangero;

  • 作者单位

    Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, CT 06106 Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511;

    Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, CT 06106 Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511;

    Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX 78229;

    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245;

    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245;

    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245;

    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245;

    Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX 78229;

    Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX 78229;

    Functional Magnetic Resonance Imaging of the Brain (FMRIB) Centre, University of Oxford, Oxford OX3 9DU, United Kingdom;

    Functional Magnetic Resonance Imaging of the Brain (FMRIB) Centre, University of Oxford, Oxford OX3 9DU, United Kingdom Department of Clinical Neuroscience, Imperial College, Hammersmith Campus, London W12 0NN, United Kingdom;

    Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX 78229;

    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    default mode; functional MRI; heritability; resting state networks;

    机译：默认模式功能性MRI;遗传力静止状态网络;

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