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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Genetic contribution to individual variation in binocular rivalry rate
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Genetic contribution to individual variation in binocular rivalry rate

机译：遗传对双眼竞争率个体变异的贡献

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摘要

Binocular rivalry occurs when conflicting images are presented in corresponding locations of the two eyes. Perception alternates between the images at a rate that is relatively stable within individuals but that varies widely between individuals. The determinants of this variation are unknown. In addition, slow binocular rivalry has been demonstrated in bipolar disorder, a psychiatric condition with high heritability. The present study therefore examined whether there is a genetic contribution to individual variation in binocular rivalry rate. We employed the twin method and studied both monozygotic (MZ) twins (n = 128 pairs) who are genetically identical, and dizygotic (DZ) twins (n = 220 pairs) who share roughly half their genes. MZ and DZ twin correlations for binocular rivalry rate were 0.51 and 0.19, respectively. The best-fitting genetic model showed 52% of the variance in binocular rivalry rate was accounted for by additive genetic factors. In contrast, nonshared environmental influences accounted for 18% of the variance, with the remainder attributed to measurement error. This study therefore demonstrates a substantial genetic contribution to individual variation in binocular rivalry rate. The results support the vigorous pursuit of genetic and molecular studies of binocular rivalry and further characterization of slow binocular rivalry as an endophenotype for bipolar disorder.
机译：当冲突的图像出现在两只眼睛的相应位置时，就会发生双眼竞争。感知在图像之间以个体内相对稳定但个体间差异很大的速率交替变化。这种变化的决定因素是未知的。此外，在双相情感障碍（一种具有高遗传力的精神疾病）中已证明了缓慢的双眼竞争。因此，本研究检查了双眼竞争率的个体变异是否有遗传因素。我们采用双胞胎方法，研究了遗传上相同的单卵双胞胎（MZ）双胞胎（n = 128对）和共有大约一半基因的双卵双胞胎（DZ）双胞胎（n = 220对）。 MZ和DZ双眼竞争率的双相关分别为0.51和0.19。最适合的遗传模型显示，双眼竞争率差异的52％是由累加遗传因素引起的。相反，非共享环境影响占方差的18％，其余部分归因于测量误差。因此，这项研究表明对双眼竞争率的个体变异有重要的遗传贡献。结果支持对双眼竞争的遗传和分子研究的积极追求，以及慢双眼竞争作为双相情感障碍的内表型的进一步表征。

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    Steven M. Miller; Narelle K. Hansell; Trung T. Ngo; Guang B. Liu; John D. Pettigrew; Nicholas G. Martin; Margaret J. Wright;

  • 作者单位

    Perceptual and Clinical Neuroscience Group and Monash Alfred Psychiatry Research Centre, School of Psychology & Psychiatry, Monash University, Melbourne, Victoria 3145, Australia;

    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia;

    Perceptual and Clinical Neuroscience Group and Monash Alfred Psychiatry Research Centre, School of Psychology & Psychiatry, Monash University, Melbourne, Victoria 3145, Australia;

    Department of Biological and Physical Sciences, Centre for Systems Biology, University of Southern Queensland, Toowoomba, Queensland 4350, Australia;

    Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia;

    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia;

    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    perceptual rivalry; bipolar disorder; endophenotype; genetics; twins;

    机译：知觉竞争躁郁症;内表型遗传学双胞胎;

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