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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Genome-wide analysis of mRNA targets for Caenorhabditis elegans FBF, a conserved stem cell regulator
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Genome-wide analysis of mRNA targets for Caenorhabditis elegans FBF, a conserved stem cell regulator

机译：秀丽隐杆线虫FBF（一种保守的干细胞调节剂）的mRNA靶标的全基因组分析

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Stem cells are essential for tissue generation during the development of multicellular creatures, and for tissue homeostasis in adults. The great therapeutic promise of stem cells makes understanding their regulation a high priority. PUF RNA-binding proteins have a conserved role in promoting self-renewal of germline stem cells. Here we use a genome-wide approach to identify putative target mRNAs for the Caenorhabditis elegans PUF protein known as FBF. We find that putative FBF targets represent ～7% of all protein-coding genes in C. elegans, implicating FBF as a broad-spectrum gene regulator. These putative FBF targets are enriched for regulators of meiotic entry and other components of the meiotic program as well as regulators of key developmental pathways. We suggest that these targets may be critical for FBF's role in stem cell maintenance. Comparison of likely FBF target mRNAs with putative PUF target mRNAs from Drosophila and humans reveals 40 shared targets, including several established stem cell regulators. We speculate that shared PUF targets represent part of a broadly used module of stem cell control.
机译：干细胞对于多细胞生物发育过程中的组织生成以及成人的组织稳态至关重要。干细胞的巨大治疗前景使了解其调控成为当务之急。 PUF RNA结合蛋白在促进种系干细胞自我更新中具有保守作用。在这里，我们使用全基因组方法来鉴定秀丽隐杆线虫PUF蛋白（称为FBF）的推定靶标mRNA。我们发现推定的FBF靶标代表线虫中所有蛋白质编码基因的约7％，这意味着FBF是广谱基因调节剂。这些推定的FBF目标丰富了减数分裂进入和减数分裂程序其他组件的调节器以及关键发育途径的调节器。我们建议这些目标可能对FBF在干细胞维持中的作用至关重要。果蝇和人类可能的FBF靶标mRNA与推定的PUF靶标mRNA的比较揭示了40个共有靶标，包括几个已建立的干细胞调节剂。我们推测共享的PUF目标代表了广泛使用的干细胞控制模块的一部分。

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