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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Compartmentalized MHC class I antigen processing enhances immunosurveillance by circumventing the law of mass action
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Compartmentalized MHC class I antigen processing enhances immunosurveillance by circumventing the law of mass action

机译:分区的MHC I类抗原加工可通过规避大规模作用定律来增强免疫监测

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摘要

MHC class I molecules function to display peptides generated from cellular and pathogen gene products for immune surveillance by CD8~+ T cells. Cells typically express ~100,000 class I molecules, or ~1 per 30,000 cellular proteins. Given "one protein, one peptide" representation, immunosurveillance would be heavily biased toward the most abundant cell proteins. Cells use several mechanisms to prevent this, including the predominant use of defective ribosomal products (DRiPs) to generate peptides from nascent proteins and, as we show here, compartmentalization of DRiP peptide generation to prevent competition from abundant cytosolic peptides. This provides an explanation for the exquisite ability of T cells to recognize peptides generated from otherwise undetected gene products.
机译:MHC I类分子的功能是展示细胞和病原体基因产物产生的肽,以供CD8〜+ T细胞免疫监视。细胞通常表达约100,000个I类分子,或每30,000个细胞蛋白约-1个。给定“一种蛋白质,一种肽”的表示,免疫监视将严重偏向最丰富的细胞蛋白质。细胞使用多种机制来防止这种情况,包括主要使用有缺陷的核糖体产物(DRiPs)从新生蛋白质中生成肽,并且如我们在此处所示,DRiP肽生成的分隔可以防止与丰富的胞质肽竞争。这为T细胞识别由其他方式未检测到的基因产物产生的肽的出色能力提供了解释。

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  • 作者单位

    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;

    Department of Microbiology and Immunology, State University of New York Upstate Medical Center, Syracuse, NY 13210;

    T Cell Laboratory, Melbourne Centre for Clinical Sciences, Ludwig Institute for Cancer Research, Austin Health, Heidelberg, Victoria 3050, Australia;

    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;

    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;

    Department of Microbiology and Immunology, State University of New York Upstate Medical Center, Syracuse, NY 13210;

    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;

    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;

    lnstitut National de la Sante et de la Recherche Medicale, Paris, France 75743;

    lnstitut National de la Sante et de la Recherche Medicale, Paris, France 75743;

    T Cell Laboratory, Melbourne Centre for Clinical Sciences, Ludwig Institute for Cancer Research, Austin Health, Heidelberg, Victoria 3050, Australia;

    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;

    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    MHC; peptide; translation; virus;

    机译:MHC;肽翻译;病毒;

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