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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Understanding gastric forces calculated from high-resolution pill tracking
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Understanding gastric forces calculated from high-resolution pill tracking

机译：了解通过高分辨率药丸跟踪计算出的胃力

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摘要

Although other methods exist for monitoring gastrointestinal motility and contractility, this study exclusively provides direct and quantitative measurements of the forces experienced by an orally ingested pill. We report motive forces and torques calculated from real-time, in vivo measurements of the movement of a magnetic pill in the stomachs of fasted and fed humans. Three-dimensional net force and two-dimensional net torque vectors as a function of time data during gastric residence are evaluated using instantaneous translational and rotational position data. Additionally, the net force calculations described can be applied to high-resolution pill tracking acquired by any modality. The fraction of time pills experience ranges of forces and torques are analyzed and correlate with the physiological phases of gastric digestion. We also report the maximum forces and torques experienced in vivo by pills as a quantitative measure of the amount of force pills experience during the muscular contractions leading to gastric emptying. Results calculated from human data are compared with small and large animal models with a translational research focus. The reported magnitude and direction of gastric forces experienced by pills in healthy stomachs serves as a baseline for comparison with pathophysiological states. Of clinical significance, the directionality associated with force vector data may be useful in determining the muscle groups associated with gastrointestinal dysmotility. Additionally, the quantitative comparison between human and animal models improves insight into comparative gastric contractility that will aid rational pill design and provide a quantitative framework for interpreting gastroretentive oral formulation test results.
机译：尽管存在其他监测胃肠道蠕动和收缩力的方法，但本研究仅提供直接和定量测量口服药片的作用力。我们报告从禁食和进食的人的胃中的磁性药丸运动的实时体内测量结果得出的动力和扭矩。使用瞬时平移和旋转位置数据，评估了胃停留期间作为时间数据函数的三维净力和二维净转矩矢量。另外，所描述的净力计算可以应用于通过任何模态获得的高分辨率药丸跟踪。时间药丸所经历的力和扭矩范围的分数被分析，并与胃消化的生理阶段相关。我们还报告了药丸在体内经历的最大力和扭矩，作为对导致胃排空的肌肉收缩期间药丸经历的量的定量测量。从人类数据计算得出的结果与以转化研究为重点的大型和大型动物模型进行比较。药丸在健康的胃中所报告的胃力的大小和方向是与病理生理状态进行比较的基准。具有临床意义的是，与力矢量数据相关的方向性可用于确定与胃肠动力异常相关的肌肉群。此外，人与动物模型之间的定量比较可提高对胃相对收缩力的了解，这将有助于合理的药丸设计并提供解释胃滞性口服制剂测试结果的定量框架。

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  • 作者

    Bryan Laulicht; Anubhav Tripathi; Vincent Schlageter; Pavel Kucera; Edith Mathiowitz;

  • 作者单位

    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912;

    rnDivision of Engineering and Medical Science, Brown University, Providence, RI 02912;

    Motilis Sari, CH-1007 Lausanne, Switzerland;

    rnMotilis Sari, CH-1007 Lausanne, Switzerland Department of Physiology, University of Lausanne, CH-1015 Lausanne, Switzerland Department of Biomedical Engineering, Czech Technical University, 166 36 Prague, Czech Republic;

    rnDepartment of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912 Division of Engineering and Medical Science, Brown University, Providence, RI 02912;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    drug delivery; gastric retention; gastrointestinal biophysics; pill science;

    机译：药物输送;胃retention留胃肠道生物物理学;药丸科学;

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