...
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Flow of energy in the outer retina in darkness and in light
【24h】

Flow of energy in the outer retina in darkness and in light

机译:在黑暗和光线下外视网膜的能量流

获取原文
获取原文并翻译 | 示例
           

摘要

Structural features of neurons create challenges for effective production and distribution of essential metabolic energy. We investigated how metabolic energy is distributed between cellular compartments in photoreceptors. In avascular retinas, aerobic production of energy occurs only in mitochondria that are located centrally within the photoreceptor. Our findings indicate that metabolic energy flows from these central mitochondria as phos-phocreatine toward the photoreceptor's synaptic terminal in darkness. In light, it flows in the opposite direction as ATP toward the outer segment. Consistent with this model, inhibition of creatine kinase in avascular retinas blocks synaptic transmission without influencing outer segment activity. Our findings also reveal how vascularization of neuronal tissue can influence the strategies neurons use for energy management. In vascularized retinas, mitochondria in the synaptic terminals of photoreceptors make neurotransmission less dependent on creatine kinase. Thus, vasculature of the tissue and the intracellular distribution of mitochondria can play key roles in setting the strategy for energy distribution in neurons.
机译:神经元的结构特征为有效产生和分配必需的代谢能量提出了挑战。我们研究了代谢能量如何在感光细胞的细胞室之间分配。在无血管的视网膜中,有氧能量的产生仅发生在位于感光体中央的线粒体中。我们的发现表明,代谢能从这些中央线粒体中以磷-磷酸肌酸的形式流向黑暗中的感光细胞突触末端。在光照下,它以与ATP相反的方向流向外部。与该模型一致,在无血管视网膜中抑制肌酸激酶可阻断突触传递,而不会影响外部区段的活性。我们的发现还揭示了神经组织的血管形成如何影响神经元用于能量管理的策略。在血管化的视网膜中,光感受器突触末端的线粒体使神经传递对肌酸激酶的依赖性降低。因此,组织的脉管系统和线粒体的细胞内分布可以在设定神经元能量分布的策略中发挥关键作用。

著录项

  • 来源
  • 作者单位

    Department of Biochemistry, University of Washington, Box 357350, Seattle, WA 98195;

    Department of Biochemistry, University of Washington, Box 357350, Seattle, WA 98195;

    Departments of Pharmacology and Experimental Neuroscience University of Nebraska Medical Center, Omaha, NE 68198 Ophthalmology and Visual Science University of Nebraska Medical Center, Omaha, NE 68198;

    Departments of Ophthalmology and Biochemistry,West Virginia University School of Medicine and West Virginia University Eye Institute, Morgantown, WV 26506;

    Department of Physiology and Biophysics, Zilkha Neurogenetic Institute, University of Southern California Keck School of Medicine, Los Angeles, CA 90089;

    Department of Biochemistry, University of Washington, Box 357350, Seattle, WA 98195;

    Department of Biochemistry, University of Washington, Box 357350, Seattle, WA 98195;

    Department of Biochemistry, University of Washington, Box 357350, Seattle, WA 98195;

    Department of Biochemistry, University of Washington, Box 357350, Seattle, WA 98195;

    Department of Otorhinolaryngology, Donders Institute of Neuroscience, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands;

    Department of Ophthalmology Research, Biomedical Centre B-13, Lund University, Lund, Sweden;

    Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands;

    Ocular Neurodegeneration Research Group, Centre for Ophthalmology, Institute for Opthalmic Research, D-72076 Tuebingen, Germany;

    Ocular Neurodegeneration Research Group, Centre for Ophthalmology, Institute for Opthalmic Research, D-72076 Tuebingen, Germany;

    Department of Biochemistry, University of Washington, Box 357350, Seattle, WA 98195;

    Department of Biochemistry, University of Washington, Box 357350, Seattle, WA 98195;

    Department of Medicine, Diabetes and Obesity Center of Excellence,University of Washington at South Lake Union, 815 Mercer Street, Box 358055, Seattle, WA 98195-8055;

    Department of Medicine, Diabetes and Obesity Center of Excellence,University of Washington at South Lake Union, 815 Mercer Street, Box 358055, Seattle, WA 98195-8055;

    Departments of Pharmacology and Experimental Neuroscience University of Nebraska Medical Center, Omaha, NE 68198 Ophthalmology and Visual Science University of Nebraska Medical Center, Omaha, NE 68198;

    Jules Stein Eye Institute, Department of Neurobiology,University of California, Los Angeles School of Medicine, Los Angeles, CA 90095;

    Jules Stein Eye Institute, Department of Neurobiology,University of California, Los Angeles School of Medicine, Los Angeles, CA 90095 Department of Biological Chemistry, University of California, Los Angeles School of Medicine, Los Angeles, CA 90095;

    Department of Physiology and Biophysics, Howard Hughes Medical Institute, Box 357370, University of Washington, Seattle, WA 98195;

    Department of Neurology and Neuroscience, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103;

    Department of Ophthalmology, University of Washington, School of Medicine, Seattle, WA 98195;

    Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands;

    Department of Physiology and Biophysics, Zilkha Neurogenetic Institute, University of Southern California Keck School of Medicine, Los Angeles, CA 90089;

    Departments of Ophthalmology and Biochemistry,West Virginia University School of Medicine and West Virginia University Eye Institute, Morgantown, WV 26506;

    Departments of Pharmacology and Experimental Neuroscience University of Nebraska Medical Center, Omaha, NE 68198 Ophthalmology and Visual Science University of Nebraska Medical Center, Omaha, NE 68198;

    Department of Biochemistry, University of Washington, Box 357350, Seattle, WA 98195;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    energy metabolism; phototransduction;

    机译:能量代谢光转导;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号