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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice
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A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice

机译：有缺陷的Il15等位基因是非肥胖糖尿病小鼠自然杀伤细胞活性不足的基础

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摘要

The nonobese diabetic (NOD) mouse strain has a genetic deficiency in natural killer (NK) cells. This defect underlies this strain's utility in several experimental settings; in particular, it promotes engraft-ment of human tissue in NOD hosts during the generation of "humanized" mouse models. We have mapped the major NK-cell defect in the NOD vs. C57BL/6 (B6) strain to an inadequately expressed 1115 allele. Treatment of NOD mice with a reagent that specifically enhances interleukin (IL)-15 bioavailability normalized NK-cell numbers and activity in the absence of nonspecific stimulation. These findings raise the possibility of exploiting reagents that impact the IL-15 receptor pathway to facilitate construction of humanized mouse models on non-NOD genetic backgrounds.
机译：非肥胖糖尿病（NOD）小鼠品系在自然杀伤（NK）细胞中具有遗传缺陷。该缺陷是该菌株在几个实验环境中的效用的基础。特别地，它在“人源化”小鼠模型的产生过程中促进了人类组织在NOD宿主中的植入。我们已经将NOD与C57BL / 6（B6）株中的主要NK细胞缺陷映射为表达不足的1115个等位基因。在不存在非特异性刺激的情况下，使用可特异性增强白介素（IL）-15生物利用度的试剂对NOD小鼠进行治疗，可将NK细胞数量和活性标准化。这些发现增加了利用影响IL-15受体途径的试剂来促进在非NOD遗传背景下构建人性化小鼠模型的可能性。

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  • 作者

    Hirotsugu Suwanai; Martha Angela Wilcox; Diane Mathis; Christophe Benoist;

  • 作者单位

    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215;

    rnSection on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215 Department of Pathology, Harvard Medical School, The Broad Institute and The Harvard Stem Cell Institute, Boston, MA 02115;

    rnSection on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215 Department of Pathology, Harvard Medical School, The Broad Institute and The Harvard Stem Cell Institute, Boston, MA 02115;

    rnSection on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215 Department of Pathology, Harvard Medical School, The Broad Institute and The Harvard Stem Cell Institute, Boston, MA 02115;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    type 1 diabetes; gene mapping; cytotoxicity; genetic variation;

    机译：1型糖尿病;基因定位细胞毒性遗传变异;

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