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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus
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Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus

机译：抑郁症的静息状态功能性MRI揭示了背侧神经网络之间的连通性增加

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摘要

To better understand intrinsic brain connections in major depression, we used a neuroimaging technique that measures resting state functional connectivity using functional MRI (fMRI). Three different brain networks-the cognitive control network, default mode network, and affective network-were investigated. Compared with controls, in depressed subjects each of these three networks had increased connectivity to the same bilateral dorsal medial prefrontal cortex region, an area that we term the dorsal nexus. The dorsal nexus demonstrated dramatically increased depression-associated fMRI connectivity with large portions of each of the three networks. The discovery that these regions are linked together through the dorsal nexus provides a potential mechanism to explain how symptoms of major depression thought to arise in distinct networks-decreased ability to focus on cognitive tasks, rumination, excessive self-focus, increased vigilance, and emotional, visceral, and autonomic dysregulation-could occur concurrently and behave synergistically. It suggests that the newly identified dorsal nexus plays a critical role in depressive symptomatology, in effect "hot wiring" networks together; it further suggests that reducing increased connectivity of the dorsal nexus presents a potential therapeutic target.
机译：为了更好地了解重度抑郁症的内在大脑连接，我们使用了一种神经影像技术，该技术使用功能性MRI（fMRI）测量静止状态的功能性连接。研究了三种不同的大脑网络-认知控制网络，默认模式网络和情感网络。与对照组相比，在抑郁的受试者中，这三个网络中的每一个都与相同的双侧背侧内侧前额叶皮层区域（我们称为背侧区域）的连通性增加。背侧神经连接显示出与抑郁相关的功能性磁共振成像连通性显着增加，三个网络中的每个网络都有很大一部分。这些区域通过背侧神经联系在一起的发现提供了一种潜在的机制，可以解释主要抑郁症的症状是如何在不同的网络中降低的，原因是它们无法专注于认知任务，反省，过度自我关注，提高警惕和情绪低落，内脏和自主神经功能失调可能同时发生并协同表现。这表明，新近发现的背侧神经网络在抑郁症状方面起着至关重要的作用，实际上是“热布线”网络的共同作用。它进一步表明减少背侧连接性的增加是潜在的治疗目标。

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  • 作者

    Yvette I. Sheline; rnJoseph L. Price; rnZhizi Yan; rnMark A. Mintun;

  • 作者单位

    Departments of Psychiatry,Washington University School of Medicine, St. Louis, MO 63110 Departments of Radiology,Washington University School of Medicine, St. Louis, MO 63110 Departments of Neurology,Washington University School of Medicine, St. Louis, MO 63110;

    rnDepartments of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110;

    rnDepartments of Radiology,Washington University School of Medicine, St. Louis, MO 63110;

    rnDepartments of Psychiatry,Washington University School of Medicine, St. Louis, MO 63110 Departments of Radiology,Washington University School of Medicine, St. Louis, MO 63110;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    blood oxygen level-dependent signal; resting state;

    机译：血氧水平依赖性信号;静止状态;

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