Supramolecular insulin assembly II for a sustained treatment of type 1 diabetes mellitus

Sarika Gupta; rnTandrika Chattopadhyay; rnMahendra Pal Singh; rnAvadhesha Surolia

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Supramolecular insulin assembly II for a sustained treatment of type 1 diabetes mellitus

机译：超分子胰岛素组装体II持续治疗1型糖尿病

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Diabetes is a chronic disease requiring continuous medical supervision and patient education to prevent acute secondary complications. In this study, we have harnessed the inherent property of insulin to aggregate into an oligomeric intermediate on the pathway to amyloid formation, to generate a form that exhibits controlled and sustained release for extended periods. Administration of a single dose of the insulin oligomer, defined here as the supramolecular insulin assembly II (SIA-II), to experimental animals rendered diabetic by streptozotocin or alloxan, released the hormone capable of maintaining physiologic glucose levels for >120 days for bovine and >140 days for recombinant human insulin without fasting hypoglycemia. Moreover, the novel SIA-II described here not only improved the glycemic control, but also reduced the extent of secondary diabetic complications.

机译：糖尿病是一种慢性疾病，需要持续的医学监督和患者教育，以防止急性继发性并发症。在这项研究中，我们利用了胰岛素的固有特性，使其聚集在淀粉样蛋白形成途径上的低聚中间体中，从而生成了可长时间控制释放和持续释放的形式。将单剂量的胰岛素低聚物（此处定义为超分子胰岛素组装体II（SIA-II））给予链脲佐菌素或四氧嘧啶致糖尿病的实验动物，可释放出这种激素，能够维持牛和猪的生理性葡萄糖水平> 120天。没有空腹低血糖的重组人胰岛素> 140天。而且，这里描述的新型SIA-II不仅改善了血糖控制，而且减少了继发性糖尿病并发症的程度。

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2010年第30期|P.13246-13251|共6页
作者
Sarika Gupta; rnTandrika Chattopadhyay; rnMahendra Pal Singh; rnAvadhesha Surolia;
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作者单位

National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India;

rnNational Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India;

rnNational Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India;

rnNational Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India Molecular Biophysics Unit, Indian Institute of Sciences, Bangalore 560012, India;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类
关键词
protein folding; hyperglycemia; normoglycemia; insulin-like growth factor-1;

机译：蛋白质折叠高血糖;常血糖胰岛素样生长因子1;

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1. Oxidative stress parameters in type I, type II and insulin-treated type 2 diabetes mellitus; insulin treatment efficiency. [J] . Seghrouchni I, Drai J, Bannier E, Clinica chimica acta: International journal of clinical chemistry and applied molecular biology . 2002,第1a2期

机译：I型，II型和胰岛素治疗的2型糖尿病的氧化应激参数;胰岛素治疗的效率。
2. Medicines for Treatment Intensification in Type 2 Diabetes and Type of Insulin in Type 1 and Type 2 Diabetes in Low-Resource Settings: Synopsis of the World Health Organization Guidelines on Second- and Third-Line Medicines and Type of Insulin for the Control of Blood Glucose Levels in Nonpregnant Adults With Diabetes Mellitus. [J] . Gojka Roglic, Susan L Norris Annals of Internal Medicine . 2018,第6期

机译：用于治疗2型糖尿病的药物和1型胰岛素的胰岛素，低资源环境中的2型糖尿病：世界卫生组织第二和第三线药物和血糖控制类型的胰蛋白酶概况和胰岛素的概要非妊娠成年人的水平患有糖尿病。
3. One week treatment with the IL-1 receptor antagonist anakinra leads to a sustained improvement in insulin sensitivity in insulin resistant patients with type 1 diabetes mellitus [J] . van Asseldonk Edwin J. P., van Poppel Pleun C. M., Ballak Dov B., Clinical immunology: The official journal of the Clinical Immunology Society . 2015,第2期

机译：用IL-1受体拮抗剂anakinra一周治疗可导致1型糖尿病胰岛素抵抗患者的胰岛素敏感性持续改善
4. Ultrasound-Induced Insulin Release as a Potential Novel Treatment for Type 2 Diabetes Mellitus [C] . Tania Singh, Ivan Suarez Castellanos, Shane Haar, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2018

机译：超声诱导的胰岛素释放作为2型糖尿病的潜在新型治疗
5. Therapeutic benefits of a soy protein rich diet in the prevention and treatment of nephropathy in young persons with type I, insulin-dependent, diabetes mellitus. [D] . Stephenson, Tammy Jean. 2001

机译：富含大豆蛋白的饮食对预防和治疗I型，胰岛素依赖型糖尿病年轻人的肾病的治疗作用。
6. Supramolecular insulin assembly II for a sustained treatment of type 1 diabetes mellitus [O] . Sarika Gupta, Tandrika Chattopadhyay, Mahendra Pal Singh, 2010

机译：超分子胰岛素组装体II持续治疗1型糖尿病
7. Supramolecular insulin assembly II for a sustained treatment of type 1 diabetes mellitus [O] . Gupta, Sarika, Chattopadhyay, Tandrika, Pal Singh, Mahendra, 2010

机译：超分子胰岛素组装体II持续治疗1型糖尿病

Supramolecular insulin assembly II for a sustained treatment of type 1 diabetes mellitus

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