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Bacteria determine fate by playing dice with controlled odds

机译:细菌通过控制赔率下骰子来决定命运

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摘要

In natural habitats, bacteria are often faced with fluctuating stressful conditions. To enhance fitness in such environments, identical cells in iso-genic populations have the capacity to stochastically differentiate into various phenotypes with special attributes (1-9). Stochastic fate determination guarantees variability because it provides each cell with the freedom to choose its own fate. This hedge survival strategy allows the population to continuously deploy specialized cells in anticipation of possible drastic changes in conditions.
机译:在自然栖息地中,细菌通常面临波动的压力条件。为了增强在这种环境中的适应性,同基因群体中的相同细胞具有随机分化为具有特殊属性的各种表型的能力(1-9)。随机命运确定可确保可变性,因为它为每个单元提供了选择自己命运的自由。这种树篱生存策略使种群能够在条件可能发生剧烈变化的情况下连续部署专门的细胞。

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    School of Physics and Astronomy, Tel Aviv University, 69978 Tel Aviv, Israel The Center for Theoretical and Biological Physics, University of California at San Diego, La Jolla, CA 92093;

    rnSchool of Physics and Astronomy, Tel Aviv University, 69978 Tel Aviv, Israel The Center for Theoretical and Biological Physics, University of California at San Diego, La Jolla, CA 92093;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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