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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Dissecting cell adhesion cross-talk with micropatterns
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Dissecting cell adhesion cross-talk with micropatterns

机译：用微模式剖析细胞粘附串扰

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摘要

A hallmark of epithelial cells is their attachment to both neighboring cells and an underlying substratum. Much research has been devoted to integrin-based substratum adhesion and cadherin-based cell-cell adhesion, both of which coordinate the underlying actin cytoskeleton. Although advances in our understanding of these dynamic structures have been rapid, what has lagged is our knowledge of how signaling and cytoskeletal changes coordinated by these systems are integrated. In PNAS, Borghi et al. (1) describe a unique approach for studying the interactions between cell-cell and cell-substratum adhesion. Using a micropatterning approach, they have accomplished the study of distinct adhesion systems in single cells.
机译：上皮细胞的标志是它们与相邻细胞和下层基底的附着。许多研究致力于基于整联蛋白的基质粘附和基于钙粘着蛋白的细胞粘附，这两者都协调了潜在的肌动蛋白细胞骨架。尽管我们对这些动态结构的理解进展很快，但我们对如何整合这些系统协调的信号传导和细胞骨架变化的了解却滞后。在PNAS中，Borghi等人。 （1）描述了一种独特的方法来研究细胞之间的相互作用和细胞-基质粘附。他们使用微图案化方法完成了单细胞中不同粘附系统的研究。

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