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A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function

机译:催产素受体基因(OXTR)中的常见等位基因会影响亲社会气质和人类下丘脑-边缘结构和功能

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摘要

The evolutionary highly conserved neuropeptide oxytocin is a key mediator of social and emotional behavior in mammals, including humans. A common variant (rs53576) in the oxytocin receptor gene (OXTR) has been implicated in social-behavioral phenotypes, such as maternal sensitivity and empathy, and with neuropsychiatric disorders associated with social impairment, but the intermediate neural mechanisms are unknown. Here, we used multimodal neuroimaging in a large sample of healthy human subjects to identify structural and functional alterations in OXTR risk allele carriers and their link to temperament. Activation and interregional coupling of the amygdala during the processing of emotionally salient social cues was significantly affected by genotype. In addition, evidence for structural alterations in key oxytocinergic regions emerged, particularly in the hypothalamus. These neural characteristics predicted lower levels of reward dependence, specifically in male risk allele carriers. Our findings identify sex-dependent mechanisms impacting the structure and function of hypothalamic-limbic circuits that are of potential clinical and translational significance.
机译:进化的高度保守的神经肽催产素是包括人类在内的哺乳动物的社交和情感行为的关键介体。催产素受体基因(OXTR)的一个常见变体(rs53576)与社会行为表型有关,例如母亲的敏感性和同情心,以及与社会障碍相关的神经精神疾病,但中间的神经机制尚不清楚。在这里,我们在健康人类受试者的大量样本中使用了多模式神经影像学,以鉴定OXTR风险等位基因携带者的结构和功能改变及其与气质的联系。基因型显着影响情感上重要的社会线索的处理过程中杏仁核的激活和区域间耦合。另外,在主要的催产毒素区域,特别是在下丘脑中,出现了结构改变的证据。这些神经特征预示着较低的奖赏依赖性水平,特别是在男性风险等位基因携带者中。我们的发现确定了影响下丘脑-limbic回路的结构和功能的性别依赖性机制,这些机制具有潜在的临床和翻译意义。

著录项

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  • 作者单位

    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892;

    rnClinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892;

    rnClinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892;

    rnClinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892;

    rnClinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892;

    rnClinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892;

    rnClinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892;

    rnClinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, 68159 Mannheim, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    imaging genetics; neuroimaging; social behavior; prosocial neuropeptides; autism;

    机译:成像遗传学;神经影像社会行为;亲社会神经肽自闭症;

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