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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Fatal attraction: Bacterial bait lures worms to their death
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Fatal attraction: Bacterial bait lures worms to their death

机译：致命吸引力：细菌诱饵诱使蠕虫死亡

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摘要

During the past decade, the roundworm Caenorhabditis elegans has become a popular model for the study of host/ pathogen relationships, leading to a wealth of information about microbial virulence factors and host defense pathways (1). Although the complicated interactions between C. elegans and the many pathogens that it encounters in the soil have become clearer in recent years, there is still much to learn. What are the cues that worms use to detect food sources? How do worms choose which bacterial species to eat and which to leave alone? Once a pathogen is encountered, what are the microbial killing mechanisms and the nematode's survival mechanisms? The paper by Niu et al. (2) in PNAS provides a rare 360° view of one C. elegans/patho-gen relationship. It describes the Bacillus nematocida signals that attract C. elegans, the virulence factors it uses to kill worms from within, and the specific host proteins targeted.
机译：在过去的十年中，the虫秀丽隐杆线虫已成为研究宿主/病原体关系的流行模型，从而获得了大量有关微生物毒力因子和宿主防御途径的信息（1）。尽管近年来秀丽线虫和它在土壤中遇到的许多病原体之间的复杂相互作用已经变得更加清晰，但仍有许多事情需要学习。蠕虫用来检测食物来源的线索是什么？蠕虫如何选择要吃哪些细菌种类，以及让它们一个人呆着？一旦遇到病原体，微生物的杀灭机制和线虫的生存机制是什么？ Niu等人的论文。 （2）在PNAS中提供了一种秀丽隐杆线虫/病原体关系的罕见360°视角。它描述了吸引线虫的线虫杆菌信号，用于从内部杀死蠕虫的毒力因子以及靶向的特定宿主蛋白。

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