...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A dynamic-signaling-team model for chemotaxis receptors in Escherichia coli
【24h】

A dynamic-signaling-team model for chemotaxis receptors in Escherichia coli

机译：大肠杆菌趋化性受体的动态信号团队模型

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The chemotaxis system of Escherichia coli is sensitive to small relative changes in ambient chemoattractant concentrations over a broad range. Interactions among receptors are crucial to this sensitivity, as is precise adaptation, the return of chemoreceptor activity to prestimulus levels in a constant chemoeffector environment through methylation and demethylation of receptors. Signal integration and cooperativity have been attributed to strongly coupled, mixed teams of receptors, but receptors become individually methylated according to their ligand occupancy states. Here, we present a model of dynamic signaling teams that reconciles strong coupling among receptors with receptor-specific methylation. Receptor trimers of dimers couple to form a honeycomb lattice, consistent with cryo-electron microscopy (cryoEM) tomography, within which the boundaries of signaling teams change rapidly. Our model helps explain the inferred increase in signaling team size with receptor modification, and indicates that active trimers couple more strongly than inactive trimers.
机译：大肠杆菌的趋化系统对周围环境趋化剂浓度的小范围相对变化敏感。受体之间的相互作用对于这种敏感性至关重要，精确的适应是在恒定的化学效应器环境中通过受体的甲基化和去甲基化使化学感受器活性恢复到刺激水平。信号整合和协同作用已归因于受体的强耦合，混合团队，但受体根据其配体占用状态而被单独甲基化。在这里，我们提出了一个动态的信号转导团队模型，该模型调和了受体之间具有受体特异性甲基化的强偶联。二聚体的受体三聚体结合形成蜂窝状晶格，这与冷冻电子显微镜（cryoEM）断层扫描法一致，其中信号传递团队的边界迅速变化。我们的模型有助于解释推断的信号分子大小随受体的修饰而增加，并表明活性三聚体比无活性三聚体的结合更牢固。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号