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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Biomechanical analysis of gait adaptation in the nematode Caenorhabditis elegans
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Biomechanical analysis of gait adaptation in the nematode Caenorhabditis elegans

机译：线虫秀丽隐杆线虫步态适应的生物力学分析

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摘要

To navigate different environments, an animal must be able to adapt its locomotory gait to its physical surroundings. The nematode Caenorhabditis elegans, between swimming in water and crawling on surfaces, adapts its locomotory gait to surroundings that impose approximately 10,000-fold differences in mechanical resistance. Here we investigate this feat by studying the undula-tory movements of C. elegans in Newtonian fluids spanning nearly five orders of magnitude in viscosity. In these fluids, the worm undulatory gait varies continuously with changes in external load: As load increases, both wavelength and frequency of undulation decrease. We also quantify the internal viscoelastic properties of the worm's body and their role in locomotory dynamics. We incorporate muscle activity, internal load, and external load into a biomechanical model of locomotion and show that (i) muscle power is nearly constant across changes in locomotory gait, and (ii) the onset of gait adaptation occurs as external load becomes comparable to internal load. During the swimming gait, which is evoked by small external loads, muscle power is primarily devoted to bending the worm's elastic body. During the crawling gait, evoked by large external loads, comparable muscle power is used to drive the external load and the elastic body. Our results suggest that C. elegans locomotory gait continuously adapts to external mechanical load in order to maintain propulsive thrust.
机译：为了在不同的环境中导航，动物必须能够使其运动步态适应其身体周围环境。线虫秀丽隐杆线虫在水中游泳和爬行在表面之间，使其机能步态适应周围环境，从而使机械阻力增加了约10,000倍。在这里，我们通过研究秀丽隐杆线虫在牛顿流体中的粘度变化近五个数量级的波动运动来研究这一壮举。在这些流体中，蠕虫的波动步态随外部负载的变化而连续变化：随着负载的增加，波动的波长和频率都会降低。我们还量化了蠕虫身体的内部粘弹性质及其在运动动力学中的作用。我们将肌肉活动，内部负荷和外部负荷纳入运动的生物力学模型中，结果表明：（i）在运动步态变化过程中，肌肉力量几乎是恒定的；（ii）当外部负荷变得可比时，步态适应发生内部负载。在很小的外部负荷引起的游泳步态中，肌肉力量主要用于弯曲蠕虫的弹性体。在爬行步态中，外部载荷较大，因此使用相当的肌肉力量来驱动外部载荷和弹性体。我们的结果表明，秀丽隐杆线虫的步态持续适应外部机械负荷，以保持推进推力。

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    Christopher Fang-Yen; Matthieu Wyart; Julie Xie; Risa Kawai; Tom Kodger; Sway Chen; Quan Wen; Aravinthan D. T. Samuel;

  • 作者单位

    Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA 02138,Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104;

    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147,Center for Soft Matter Research,New York University, New York, NY 10003;

    Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA 02138;

    Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA 02138;

    School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138;

    Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA 02138;

    Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA 02138,Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147;

    Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA 02138;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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